Neurobiological Component Report

Name	Noradrenergic system
Description	Norepinephrine (noradrenaline; NE, NA) is a catecholamine with multiple roles including as a hormone and a neurotransmitter. Areas of the body that produce or are affected by norepinephrine are described as noradrenergic. Norepinephrine is synthesized from dopamine by dopamine beta-hydroxylase. It is released from the adrenal medulla into the blood as a hormone, and is also a neurotransmitter in the central nervous system and sympathetic nervous system where it is released from noradrenergic neurons in the locus coeruleus. The actions of norepinephrine are carried out via the binding to adrenergic receptors.
No. of Studies (Positive/Negative)	2 (2/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
noradrenergic system	Shibata, 2007	patients and normal controls		In patients, contrast ratios in the rostral and middle porti...... In patients, contrast ratios in the rostral and middle portions were significantly decreased in comparison with controls, suggesting dysfunction of the ascending noradrenergic system. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
noradrenergic (NE) systems		Depressed mood(depressed mood)	symptoms	Katz, 1994	patients only		Drug-induced changes in NE primarily with the psychomotor, s...... Drug-induced changes in NE primarily with the psychomotor, secondarily with the mood components of the depressed state More...
noradrenergic (NE) systems		Increased agitation(psychomotor change)	symptoms	Katz, 1994	patients only		Drug-induced changes in NE primarily with the psychomotor, s...... Drug-induced changes in NE primarily with the psychomotor, secondarily with the mood components of the depressed state More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Name	Type
Amygdala	brain morphology and function
Locus coeruleus	brain morphology and function
Cingulate gyrus	brain morphology and function
Hippocampus	brain morphology and function
Cingulum	brain morphology and function
Hypothalamus	brain morphology and function
Striatum	brain morphology and function
Thalamus	brain morphology and function
Norepinephrine	molecule
adrenal medulla	other