Cell Report

Name	Neuroglia
Description	The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
No. of Studies (Positive/Negative)	7(7/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
glia	Ongur, 1998	patients and normal controls		The numbers of glia were reduced markedly in both MDD and BD...... The numbers of glia were reduced markedly in both MDD and BD. More...
Glial cell	Cotter, 2001	patients and normal controls	P-value-value=0.004; P-value-value=0.01	Glial cell density (22%) (P =.004) and neuronal size (23%) (...... Glial cell density (22%) (P =.004) and neuronal size (23%) (P =.01) were reduced in layer 6 in major depressive disorder compared with controls. More...
glial cell	Cotter, 2002	patients and normal controls	P-value-value=0.007; P-value-value=0.003	In MDD, we observed reductions in glial cell density (30%; P...... In MDD, we observed reductions in glial cell density (30%; P = 0.007) in layer 5 and neuronal size (20%; P = 0.003) in layer 6. More...
Glial	Bowley, 2002	patients and normal controls		Glial density and the glia/neuron ratio were substantially r...... Glial density and the glia/neuron ratio were substantially reduced in the amygdala in major depressive disorder cases. The reduction was mainly accounted for by counts in the left hemisphere. More...
glia	Hamidi, 2004	patients and normal controls		The density of total glia and oligodendrocytes in the amygda...... The density of total glia and oligodendrocytes in the amygdala was significantly lower in MDD than in control subjects More...
glia	Stockmeier, 2004	patients and normal controls		The density of granule cells and glia in the dentate gyrus a...... The density of granule cells and glia in the dentate gyrus and pyramidal neurons and glia in all cornv ammonis (CA)/hippocampal subfields is significantly increased by 30%-35% in MDD. More...
glia	Rajkowska, 2005	patients and normal controls		In MDD the density of nonpyramidal neurons and glia and cort...... In MDD the density of nonpyramidal neurons and glia and cortical and laminar width were comparable to control values. More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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