MK4MDD

Gene Report

Basic Information
Approved Symbol MTHFR
Approved Name methylenetetrahydrofolate reductase (NAD(P)H)
Previous Name "5,10-methylenetetrahydrofolate reductase (NADPH)"
Location 1p36.3
Position chr1:11865945-11865965 (-)
External Links Entrez Gene: 4524
Ensembl: ENSG00000177000
UCSC: uc001atc.2
HGNC ID: 7436
No. of Studies (Positive/Negative) 5(1/4) Help
Type Literature-origin; SNP mapped

Positive relationships between MTHFR and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
MTHFR Shen, 2014 Patients and nomal controls T allele (OR=1.81; CI95%=1.40¨C2.34, P<0.001); C/T genotype (OR=3.66; CI95% =2.53¨C5.28, P<0.001) The T allele (OR=1.81; CI95%=1.40¨C2.34, P<0.001) and C/T ge...... The T allele (OR=1.81; CI95%=1.40¨C2.34, P<0.001) and C/T genotype (OR=3.66; CI95% =2.53¨C5.28, P<0.001) of MTHFR C677T were significantly different between case and control groups. More...

Positive relationships between MTHFR and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of MTHFR in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between MTHFR and MDD (count: 3)
Name in Literature Reference Research Type Statistical Result Relation Description
MTHFR Gaysina D, 2008 Patients and nomal controls no significant differences in genotype or allele frequencies...... no significant differences in genotype or allele frequencies between depressive patients and controls were observed. More...
MTHFR Evinova A, 2012 patients and normal controls We found no significant association of either the BDNF G196A...... We found no significant association of either the BDNF G196A or MTHFR C677T polymorphisms with major depressive disorder neither in female nor male group of patients. More...
MTHFR Gabriela Nielsen, 2015 Patients and nomal controls For both SNPs of the MTHFR gene, the results did not show an...... For both SNPs of the MTHFR gene, the results did not show any differences in genotype and allele distributions between MDD and controls.However, for A1298C we found a significant interaction between gender and allele A carriers (F=4.84; p=0.03). Secondary analyses showed that A1298C CC homozygotes were more frequent in female MDD patients than female controls (F=6.50,p=0.01, OR=1.97, 95%CI:1.03¨C3.61; Table 4B). More...

Negative relationships between MTHFR and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


MTHFR related SNPs in MK4MDD (count: 2)
MTHFR related proteins in MK4MDD (count: 0)
MTHFR related GO terms (count: 26)
MTHFR related KEGG pathways (count: 1)
MTHFR related BioCarta pathways (count: 0)
MTHFR related Reactome pathways (count: 1)
MTHFR related interactors from protein-protein interaction data in HPRD (count: 1)