Brain Morphology and Function Report

Name	Locus coeruleus
Brain Morphology	The locus coeruleus (also spelled locus caeruleus or locus ceruleus), is a nucleus in the brainstem involved with physiological responses to stress and panic. The locus coeruleus is the principal site for brain synthesis of norepinephrine (noradrenaline). The locus coeruleus and the areas of the body affected by the norepinephrine it produces are described collectively as the locus coeruleus-noradrenergic system or LC-NA system. Norepinephrine may also be released directly into the blood from the adrenal medulla.
Brain Function	The locus coeruleus (also spelled locus caeruleus or locus ceruleus), is a nucleus in the brainstem involved with physiological responses to stress and panic.
No. of Studies (Positive/Negative)	3(3/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
locus coeruleus	Ordway, 2003	patients and normal controls		The specific binding of p-[125I]iodoclonidine to alpha2-adre...... The specific binding of p-[125I]iodoclonidine to alpha2-adrenoceptors was significantly elevated throughout the LC (locus coeruleus) from MD (major depression) compared with matched control subjects. More...
noradrenergic locus coeruleus	Karolewicz, 2004	patients and normal controls	P-value < 0.05, - 44%	Levels of nNOS immunoreactivity were significantly lower in ...... Levels of nNOS immunoreactivity were significantly lower in the LC (- 44%, p < 0.05), but not in the cerebellum, when comparing depressed with control subjects. More...
locus ceruleus	Shibata, 2007	patients and normal controls		In patients, contrast ratios in the rostral and middle porti...... In patients, contrast ratios in the rostral and middle portions (of the locus ceruleus) were significantly decreased in comparison with controls, More...

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Note:
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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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