MK4MDD

Brain Morphology and Function Report

Basic Information
Name Locus coeruleus
Brain Morphology "The locus coeruleus (also spelled locus caeruleus or locus ceruleus), is a nucleus in the brainstem involved with physiological responses to stress and panic. The locus coeruleus is the principal site for brain synthesis of norepinephrine (noradrenaline). The locus coeruleus and the areas of the body affected by the norepinephrine it produces are described collectively as the locus coeruleus-noradrenergic system or LC-NA system. Norepinephrine may also be released directly into the blood from the adrenal medulla."
Brain Function "The locus coeruleus (also spelled locus caeruleus or locus ceruleus), is a nucleus in the brainstem involved with physiological responses to stress and panic."
No. of Studies (Positive/Negative) 3(3/0) Help

Positive relationships between Locus coeruleus and MDD (count: 3)
Name in Literature Reference Research Type Statistical Result Relation Description Help
locus coeruleus Ordway, 2003 patients and normal controls The specific binding of p-[125I]iodoclonidine to alpha2-adre...... The specific binding of p-[125I]iodoclonidine to alpha2-adrenoceptors was significantly elevated throughout the LC (locus coeruleus) from MD (major depression) compared with matched control subjects. More...
noradrenergic locus coeruleus Karolewicz, 2004 patients and normal controls P-value < 0.05, - 44% Levels of nNOS immunoreactivity were significantly lower in ...... Levels of nNOS immunoreactivity were significantly lower in the LC (- 44%, p < 0.05), but not in the cerebellum, when comparing depressed with control subjects. More...
locus ceruleus Shibata, 2007 patients and normal controls In patients, contrast ratios in the rostral and middle porti...... In patients, contrast ratios in the rostral and middle portions (of the locus ceruleus) were significantly decreased in comparison with controls, More...

Positive relationships between Locus coeruleus and other components at different levels (count: 0) Help
Positive relationship network of Locus coeruleus in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Locus coeruleus and MDD (count: 0)
Negative relationships between Locus coeruleus and other components at different levels (count: 0) Help