Molecule Report

Name	Lipoproteins, HDL
Description	A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.
MeSH ID	D008075
No. of Studies (Positive/Negative)	2(2/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
high-density lipoprotein	Huang, 2003	patients and normal controls		The ratios of TC/HDL and low-density lipoprotein (LDL)/HDL s...... The ratios of TC/HDL and low-density lipoprotein (LDL)/HDL showed significant differences between patients with major depressive disorder and normal controls in women More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
high-density lipoprotein		Executive functions(executive functioning)	cognition and behavior	Smith, 2007	patients only	b = 1.03; P-value = 0.035	Lower high-density lipoprotein levels also were associated w...... Lower high-density lipoprotein levels also were associated with poorer executive functioning (b = 1.03; p = .035). More...

---

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web