Gene Report

Basic Information

Approved Symbol	LILRB1
Approved Name	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
Symbol Alias	LIR-1, ILT2, MIR-7, CD85, LIR1, CD85j
Location	19q13.4
Position	chr19:55148330-55149007 (+)
External Links	Entrez Gene: 10859 UCSC: uc002qgm.3 HGNC ID: 6605
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin; Protein mapped

Positive relationships between LILRB1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
ILR1	Carvalho LA, 2014	patients and normal controls	FC=1.3; P-value=0.027	Thirty-four of the 47 monocyte inflammatory-related genes w...... Thirty-four of the 47 monocyte inflammatory-related genes were significantly upregulated and 2 were significantly downregulated as compared to controls More...

Positive relationships between LILRB1 and other components at different levels (count: 0)

Positive relationship network of LILRB1 in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between LILRB1 and MDD (count: 0)

Negative relationships between LILRB1 and other components at different levels (count: 0)

LILRB1 related SNPs in MK4MDD (count: 0)

LILRB1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Leukocyte immunoglobulin-like receptor subfamily B member 1	Q8NHL6	1(0/1)	Literature-origin

LILRB1 related GO terms (count: 53)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:2001205	negative regulation of osteoclast development	biological process	IDA[18802077]
GO:0005886	plasma membrane	cellular component	TAS
GO:0050776	regulation of immune response	biological process	TAS
GO:0045919	positive regulation of cytolysis	biological process	IDA[18684926]; IMP[21233315]
GO:0001915	negative regulation of T cell mediated cytotoxicity	biological process	IDA[21213105]
GO:0032689	negative regulation of interferon-gamma production	biological process	IDA[17869268]
GO:2001186	negative regulation of CD8-positive, alpha-beta T cell activation	biological process	IDA[21213105]
GO:0032609	interferon-gamma production	biological process	IDA[11907092]
GO:0042536	negative regulation of tumor necrosis factor biosynthetic process	biological process	IDA[18684926]
GO:0051607	defense response to virus	biological process	IDA[15585844]
GO:0042803	protein homodimerization activity	molecular function	IPI[21213105]
GO:2001180	negative regulation of interleukin-10 secretion	biological process	IDA[18094328]
GO:0032945	negative regulation of mononuclear cell proliferation	biological process	IDA[21551166]
GO:0030109	HLA-B specific inhibitory MHC class I receptor activity	molecular function	IDA[11907092]
GO:0005737	cytoplasm	cellular component	IDA[15585844]
GO:0002250	adaptive immune response	biological process	IEA
GO:0016021	integral component of membrane	cellular component	IEA
GO:0072643	interferon-gamma secretion	biological process	IDA[15585844]
GO:0014063	negative regulation of serotonin secretion	biological process	IDA[11907092]
GO:0031623	receptor internalization	biological process	TAS[17869268]
GO:0002767	immune response-inhibiting cell surface receptor signaling pathway	biological process	NAS[18550825]
GO:0051926	negative regulation of calcium ion transport	biological process	IDA[9842885]
GO:2001202	negative regulation of transforming growth factor-beta secretion	biological process	IDA[18094328]
GO:0071222	cellular response to lipopolysaccharide	biological process	IEP[18094328]
GO:0002740	negative regulation of cytokine secretion involved in immune response	biological process	IDA[18094328]
GO:0030107	HLA-A specific inhibitory MHC class I receptor activity	molecular function	IDA[18684926]
GO:0045806	negative regulation of endocytosis	biological process	IDA[18094328]
GO:0042288	MHC class I protein binding	molecular function	IDA[9842885\|18094328\|18802077\|21213105]; IMP[18398485\|21233315]; IPI[9285411\|17869268\|18094328\|19124746\|20702625]
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	NAS[18550825]
GO:2001183	negative regulation of interleukin-12 secretion	biological process	IDA[18094328]
GO:0008157	protein phosphatase 1 binding	molecular function	IPI[9285411\|9842885\|11907092\|18802077]
GO:0007165	signal transduction	biological process	IDA[18802077]
GO:0045786	negative regulation of cell cycle	biological process	IDA[21551166]
GO:0043065	positive regulation of apoptotic process	biological process	IDA[21551166]
GO:0045077	negative regulation of interferon-gamma biosynthetic process	biological process	IDA[18684926]
GO:0002309	T cell proliferation involved in immune response	biological process	IDA[18094328]
GO:2001189	negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	biological process	IDA[18094328]
GO:2001193	positive regulation of gamma-delta T cell activation involved in immune response	biological process	IDA[21233315]
GO:0005576	extracellular region	cellular component	IEA
GO:2000669	negative regulation of dendritic cell apoptotic process	biological process	IDA[18094328]
GO:0032393	MHC class I receptor activity	molecular function	IDA[9285411\|9842885\|17869268\|18094328\|18398485\|18802077\|21213105\|21233315]
GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	biological process	IDA[18398485]
GO:2001199	negative regulation of dendritic cell differentiation	biological process	IMP[18684926]
GO:0009615	response to virus	biological process	IDA[9285411\|17869268\|18094328]
GO:0042169	SH2 domain binding	molecular function	IDA[11907092]
GO:0009897	external side of plasma membrane	cellular component	IDA[9285411\|15585844\|17869268\|18094328\|18684926\|21233315\|21551166]
GO:0046636	negative regulation of alpha-beta T cell activation	biological process	IDA[21213105]
GO:0097028	dendritic cell differentiation	biological process	IEP[18094328]
GO:0042130	negative regulation of T cell proliferation	biological process	IDA[15585844]
GO:0002230	positive regulation of defense response to virus by host	biological process	IDA[18398485]
GO:0035548	negative regulation of interferon-beta secretion	biological process	IDA[21213105]
GO:0002774	Fc receptor mediated inhibitory signaling pathway	biological process	IDA[9842885]
GO:0010628	positive regulation of gene expression	biological process	IDA[18094328]

LILRB1 related KEGG pathways (count: 0)

LILRB1 related BioCarta pathways (count: 0)

LILRB1 related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_11152	immunoregulatory interactions_between_a_lymphoid_and_a_non_lymphoid_cell	A number of receptors and cell adhesion molecules play a key...... A number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathogenic organisms. Molecules such as KIRs and LILRs form part of a crucial surveillance system that looks out for any derangement, usually caused by cancer or viral infection, in MHC Class I presentation. Somatic cells are also able to report internal functional impairment by displaying surface stress markers such as MICA. The presence of these molecules on somatic cells is picked up by C-lectin NK immune receptors. Lymphoid cells are able to regulate their location and movement in accordance to their state of activation, and home in on tissues expressing the appropriate complementary ligands. For example, lymphoid cells may fine tune the presence and concentration of adhesion molecules belonging to the IgSF, Selectin and Integrin class that interact with a number of vascular markers of inflammation. Furthermore, there are a number of avenues through which lymphoid cells may interact with antigen. This may be presented directly to a specific T-cell receptor in the context of an MHC molecule. Antigen-antibody complexes may anchor to the cell via a small number of lymphoid-specific Fc receptors that may, in turn, influence cell function further. Activated complement factor C3d binds to both antigen and to cell surface receptor CD21. In such cases, the far-reaching influence of CD19 on B-lymphocyte function is tempered by its interaction with CD21. More...
REACT_6900	signaling in_immune_system	Humans are exposed to millions of potential pathogens daily,...... Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system. More...

LILRB1 related interactors from protein-protein interaction data in HPRD (count: 6)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
LILRB1	HLA-C	No	in vitro	12853576
LILRB1	HLA-F	No	in vivo	11169396
LILRB1	HLA-G	No	in vitro;in vivo	9933109 , 12853576 , 12874224
LILRB1	HLA-A	No	in vitro	12897781
LILRB1	HLA-B	No	in vitro	12853576
LILRB1	B2M	No	in vitro	12897781

Gene Report

Gene mapped GO terms

Gene mapped Reactome pathways