Gene Report

Basic Information

Approved Symbol	LGALS3
Approved Name	lectin, galactoside-binding, soluble, 3
Previous Symbol	LGALS2
Symbol Alias	MAC-2, GALIG
Name Alias	galectin 3
Location	14q22.3
Position	chr14:55595935-55612148 (+)
External Links	Entrez Gene: 3958 Ensembl: ENSG00000131981 UCSC: uc001xbr.3 HGNC ID: 6563
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin

Positive relationships between LGALS3 and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Galectin 3	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression
LGALS3	Chu TT, 2009	Patients and nomal controls		Down regulation, fold change([MD] vs [C]) 4.3278337 Down regulation, fold change([MD] vs [C]) 4.3278337

Positive relationships between LGALS3 and other components at different levels (count: 0)

Positive relationship network of LGALS3 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between LGALS3 and MDD (count: 0)

Negative relationships between LGALS3 and other components at different levels (count: 0)

LGALS3 related SNPs in MK4MDD (count: 0)

LGALS3 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Galectin-3	P17931	0(0/0)	Gene mapped

LGALS3 related GO terms (count: 16)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006397	mRNA processing	biological process	IEA
GO:0019863	IgE binding	molecular function	IEA
GO:0008380	RNA splicing	biological process	IEA
GO:0005737	cytoplasm	cellular component	IDA[14961764]
GO:0005681	spliceosomal complex	cellular component	IEA
GO:0005578	proteinaceous extracellular matrix	cellular component	IEA
GO:0045087	innate immune response	biological process	TAS
GO:0030198	extracellular matrix organization	biological process	IEA
GO:0001501	skeletal system development	biological process	IEA
GO:0030246	carbohydrate binding	molecular function	IEA
GO:0005743	mitochondrial inner membrane	cellular component	IDA[19016746]
GO:0030154	cell differentiation	biological process	IEA
GO:0031012	extracellular matrix	cellular component	IDA
GO:0005634	nucleus	cellular component	IDA[14961764]
GO:0005515	protein binding	molecular function	IPI[19016746]
GO:0005886	plasma membrane	cellular component	TAS[9162064]

LGALS3 related KEGG pathways (count: 0)

LGALS3 related BioCarta pathways (count: 0)

LGALS3 related Reactome pathways (count: 0)

LGALS3 related interactors from protein-protein interaction data in HPRD (count: 13)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
LGALS3	CYHR1	No	in vitro;yeast 2-hybrid	10745073
LGALS3	CUBN	No	in vitro	11856751
LGALS3	CSNK2A1	No	in vitro;in vivo	10961987 , 8253806
LGALS3	MMP2	No	in vitro	7947821
LGALS3	MYOC	No	yeast 2-hybrid	16289162
LGALS3	CSNK2A2	No	in vitro;in vivo	10961987 , 8253806
LGALS3	ELN	No	in vitro;in vivo	10536372
LGALS3	SUFU	No	in vitro;yeast 2-hybrid	14611647
LGALS3	LIM2	No	in vivo	11532191
LGALS3	GEMIN4	No	in vitro;in vivo	11522829
LGALS3	FCGR2A	No	in vitro	10704522
LGALS3	CSNK1A1	No	in vitro;in vivo	10961987 , 8253806
LGALS3	LGALS3BP	No	in vitro;in vivo	8813152 , 8390986 , 1917996

Gene Report

Gene mapped GO terms