Protein Report

Protein Name	Interleukin-2 receptor subunit alpha
UniPortKB	P01589
No. of Studies (Positive/Negative)	2 (2/0)
Type	Literature-origin

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
interleukin-2 receptor	Wichers, 2006	high-risk people		Baseline soluble interleukin-2 receptor (sIL-2r), interleuki...... Baseline soluble interleukin-2 receptor (sIL-2r), interleukin-6 (IL-6), and interleukin-10 (IL-10) concentrations were significantly increased in the five subjects that developed MDD during treatment compared with those that did not, with standardized effect sizes of 1.08, 1.16, and 1.25, respectively, controlling for marijuana use, cigarette smoking, and baseline level of depressive symptoms. More...
soluble interleukin-2 receptor (sIL-2R)	Eller, 2009	patients and normal controls		The results showed that the level of sIL-2R (soluble interle...... The results showed that the level of sIL-2R (soluble interleukin-2 receptor) was significantly lower in depressed patients in remission phase compared to the healthy controls and subjects with recurrent depression. Drug-nalve patients with major depressive disorder with recurrent episode had higher levels of sIL-2R than previously treated or patients with the first episode. More...

Name in Literature	Related Components
	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
soluble interleukin-2 receptor (sIL-2R)		Increased agitation(agitation)	symptoms	Eller, 2009	patients and normal controls		Further analysis of patients revealed that sIL-2R was positi...... Further analysis of patients revealed that sIL-2R was positively correlated with decreased activity and agitation. More...
soluble interleukin-2 receptor (sIL-2R)		Depressed mood(depressed mood)	symptoms	Eller, 2009	patients and normal controls		Further analysis of patients revealed that sIL-2R was positi...... Further analysis of patients revealed that sIL-2R was positively correlated with decreased activity and agitation. More...

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1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
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Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
IL2RA	interleukin 2 receptor, alpha	Protein mapped	0 (0/0)