Gene Report

Basic Information

Approved Symbol	ITIH4
Approved Name	inter-alpha-trypsin inhibitor heavy chain family, member 4
Previous Symbol	ITIHL1
Previous Name	inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)
Symbol Alias	IHRP, H4P
Name Alias	plasma Kallikrein-sensitive glycoprotein
Location	3p21.1
Position	chr3:52847006-52864717 (-)
External Links	Entrez Gene: 3700 Ensembl: ENSG00000055955 UCSC: uc003dfz.3 HGNC ID: 6169
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between ITIH4 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Inter-alpha (globulin) inhibitor H4	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between ITIH4 and other components at different levels (count: 0)

Positive relationship network of ITIH4 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between ITIH4 and MDD (count: 0)

Negative relationships between ITIH4 and other components at different levels (count: 0)

ITIH4 related SNPs in MK4MDD (count: 0)

ITIH4 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Inter-alpha-trypsin inhibitor heavy chain H4	Q14624	0(0/0)	Gene mapped

ITIH4 related GO terms (count: 10)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0030212	hyaluronan metabolic process	biological process	IEA
GO:0010951	negative regulation of endopeptidase activity	biological process	TAS[9756925]
GO:0004867	serine-type endopeptidase inhibitor activity	molecular function	IEA
GO:0005886	plasma membrane	cellular component	IEA
GO:0005515	protein binding	molecular function	IPI[16271702]
GO:0005737	cytoplasm	cellular component	IEA
GO:0004866	endopeptidase inhibitor activity	molecular function	TAS[9756925]
GO:0034097	response to cytokine stimulus	biological process	IEP[10486281]
GO:0006953	acute-phase response	biological process	IEP[19263524]
GO:0005576	extracellular region	cellular component	NAS[14718574]

ITIH4 related KEGG pathways (count: 0)

ITIH4 related BioCarta pathways (count: 0)

ITIH4 related Reactome pathways (count: 0)

ITIH4 related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Gene mapped GO terms