Neurobiological Component Report

Name	Gamma-aminobutyric acid (GABA)ergic system
Description	gamma-Aminobutyric acid or GABA is the chief inhibitory neurotransmitter in the mammalian central nervous system. It plays a role in regulating neuronal excitability throughout the nervous system. In humans, GABA is also directly responsible for the regulation of muscle tone. In vertebrates, GABA acts at inhibitory synapses in the brain by binding to specific transmembrane receptors in the plasma membrane of both pre- and postsynaptic neuronal processes. Two general classes of GABA receptor are known: GABAA in which the receptor is part of a ligand-gated ion channel complex, and GABAB metabotropic receptors, which are G protein-coupled receptors that open or close ion channels via intermediaries (G proteins).
Picture	From Wiki.
No. of Studies (Positive/Negative)	2 (2/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
gamma-aminobutyric acid (GABA)ergic system	Klumpers, 2010	patients and normal controls		Major depressive disorder (MDD) has been related to both a d...... Major depressive disorder (MDD) has been related to both a dysfunctional gamma-amino butyric acid (GABA) system and to hyperactivity of the hypothalamic-pituitary-adrenal axis (HPA). More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
gamma-aminobutyric acid (GABA)ergic system		Calbindin(calbindin)	protein	Maciag, 2010	patients and normal controls		GABAergic neurons GABAergic neurons
gamma-aminobutyric acid (GABA)ergic system		Hypothalamic-pituitary-adrenal axis(hypothalamic-pituitary-adrenal axis (HPA))	neurobiological system	Klumpers, 2010	patients and normal controls		In the temporal area, [(11)C]FMZ binding showed a strong inv...... In the temporal area, [(11)C]FMZ binding showed a strong inverse correlation with HPA axis activity. The inverse relationship between GABA(A) binding in the temporal lobe and HPA axis activity, suggests that HPA axis hyperactivity is partly due to reduced GABA-ergic inhibition. More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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3. The network is generated using Cytoscape Web

Name	Type
Hippocampus	brain morphology and function
glutamateergic synapses	cell
medium spiny cells	cell
chandelier cell	cell
gamma-Aminobutyric Acid	molecule
Gamma-aminobutyric acid type B receptor subunit 1	protein
GABAA receptors	protein
Gamma-aminobutyric acid type B receptor subunit 2	protein
Gamma-aminobutyric acid receptor subunit alpha-1	protein
Gamma-aminobutyric acid receptor subunit alpha-2	protein
Gamma-aminobutyric acid receptor subunit alpha-3	protein
Gamma-aminobutyric acid receptor subunit alpha-4	protein
Gamma-aminobutyric acid receptor subunit alpha-5	protein
Gamma-aminobutyric acid receptor subunit alpha-6	protein
Gamma-aminobutyric acid receptor subunit beta-1	protein
Gamma-aminobutyric acid receptor subunit beta-2	protein
Gamma-aminobutyric acid receptor subunit beta-3	protein
Gamma-aminobutyric acid receptor subunit gamma-1	protein
Gamma-aminobutyric acid receptor subunit gamma-2	protein
Gamma-aminobutyric acid receptor subunit gamma-3	protein
Gamma-aminobutyric acid receptor subunit delta	protein
Gamma-aminobutyric acid receptor subunit epsilon	protein
Gamma-aminobutyric acid receptor subunit pi	protein
Gamma-aminobutyric acid receptor subunit theta	protein