Brain Morphology and Function Report

Name	Entorhinal cortex
Brain Morphology	The entorhinal cortex (EC) is located in the medial temporal lobe and functions as a hub in a widespread network for memory and navigation.
Brain Function	The EC is the main interface between the hippocampus and neocortex. The EC-hippocampus system plays an important role in autobiographical/declarative/episodic memories and in particular spatial memories including memory formation, memory consolidation, and memory optimization in sleep. The EC is also responsible for the pre-processing (familiarity) of the input signals in the reflex nictitating membrane response of classical trace conditioning, the association of impulses from the eye and the ear occurs in the entorhinal cortex.
No. of Studies (Positive/Negative)	2(2/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
entorhinal cortex	Uezato, 2009	patients and normal controls		We found decreased VGLUT1 mRNA expression in both MDD and BD...... We found decreased VGLUT1 mRNA expression in both MDD and BD in the entorhinal cortex (ERC), decreased VGLUT2 mRNA expression in MDD in the middle temporal gyrus More...
entorhinal cortex	Gerritsen, 2011	high-risk people	P-value < .05	Remitted MDD was related to smaller entorhinal cortex volume...... Remitted MDD was related to smaller entorhinal cortex volumes (p < .05). More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web