Neurobiological Component Report

Name	Electroencephalographic activity
Description	Electroencephalography (EEG) is the recording of electrical activity along the scalp. EEG measures voltage fluctuations resulting from ionic current flows within the neurons of the brain. The brain's electrical charge is maintained by billions of neurons. Scalp EEG activity shows oscillations at a variety of frequencies. Several of these oscillations have characteristic frequency ranges, spatial distributions and are associated with different states of brain functioning (e.g., waking and the various sleep stages). These oscillations represent synchronized activity over a network of neurons.
No. of Studies (Positive/Negative)	5 (5/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
electroencephalographic rhythms	Morehouse, 2002	high-risk people and normal controls		Temporal coherence (temporal coherence of ultradian sleep el...... Temporal coherence (temporal coherence of ultradian sleep electroencephalographic rhythms) was significantly lower among the high-risk girls than in controls. Low temporal coherence is evident in adolescent girls at high risk for depression. More...
electroencephalographic mean frequency	Silveira, 2010	patients only		Our cross-sectional study showed that a lower mean frequency...... Our cross-sectional study showed that a lower mean frequency (MF) in posterior areas is related to depression in the elderly. More...
electroencephalographic asymmetry	Stewart, 2011	patients and normal controls		Past MDD+ women displayed relatively less right parietal act...... Past MDD+ women displayed relatively less right parietal activity than current MDD+ and MDD- women, replicating prior work. More...
electroencephalographic asymmetry	Stewart, 2010	patients and normal controls		Lifetime MDD was linked to relatively less left frontal acti...... Lifetime MDD was linked to relatively less left frontal activity for both sexes using a current source density (CSD) reference, findings that were not accounted for solely by current MDD status or current depression severity, suggesting that CSD-referenced EEG asymmetry is a possible endophenotype for depression. More...
electroencephalographic asymmetry	Kemp, 2010	patients and normal controls		reduced left-frontal electroencephalographic activity in MDD reduced left-frontal electroencephalographic activity in MDD

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
electroencephalographic mean frequency		Physical exercise(physical exercise)	environment	Silveira, 2010	patients only		We observed that depressed elderly individuals showed a bett...... We observed that depressed elderly individuals showed a better response to treatment and an increase in MF(mean frequency) after physical training. More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web