Brain Morphology and Function Report

Name	Corpus callosum
Brain Morphology	The corpus callosum (Latin: tough body), also known as the colossal commissure, is a wide, flat bundle of neural fibers beneath the cortex in the eutherian brain at the longitudinal fissure. It connects the left and right cerebral hemispheres and facilitates interhemispheric communication. It is the largest white matter structure in the brain, consisting of 200-250 million contralateral axonal projections.
No. of Studies (Positive/Negative)	5(5/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
corpus callosum	Kumar, 2004	patients and normal controls		Patients had significantly lower MTRs(Magnetization transfer...... Patients had significantly lower MTRs(Magnetization transfer ratios) in the genu and splenium of the corpus callosum, the right caudate nucleus and putamen, and the occipital white matter compared with controls. More...
corpus callosum (CC)	Lacerda, 2005	patients and normal controls		Our findings suggest that anatomical abnormalities in CC may...... Our findings suggest that anatomical abnormalities in CC may be restricted to patients with familial MDD, with possible enlargement of CC in this particular sub-group. Patients with familial MDD had a significantly larger middle genu area (F(1,45)=4.252; p=0.045) compared to healthy controls, and significantly larger middle genu (F(1,13)=5.366; p=0.037), anterior splenium (F(1,13)=6.27; p=0.026), and middle splenium areas (F(1,13)=4.706; p=0.049) compared to patients with non-familial MDD. More...
corpus callosum	Kieseppa, 2010	patients and normal controls		Compared with controls, the MDD patients showed a trend for ...... Compared with controls, the MDD patients showed a trend for lower values of fractional anisotropy (FA) in the left sagittal stratum, and suggestive decreased FA in the right cingulate cortex and posterior body of corpus callosum. More...
corpus callosum	Korgaonkar, 2010	patients and normal controls	average reduction of 7.8%	Compared with controls, melancholic participants showed an a...... Compared with controls, melancholic participants showed an average reduction of 7.8% in fractional anisotropy over WM regions associated with the limbic system, dorsolateral prefrontal cortex, thalamic projection fibers, corpus callosum, and other association fibers. More...
corpus callosum	Frodl, 2012	high-risk people and normal controls		The unaffected first-degree healthy relatives (UHRs) showed ...... The unaffected first-degree healthy relatives (UHRs) showed greater fractional anisotropy than controls in the body and splenium of the corpus callosum, More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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3. The network is generated using Cytoscape Web