Signs Report

Name	Coronary flow reserve
Description	Coronary flow reserve (CFR) is the ratio of maximum flow during stress (in response to adenosine in the present study) to flow at rest measured in milliliters per minute per gram of tissue, an integrated measure of whole coronary circulation. In the absence of coronary stenosis, CFR provides an index of coronary vasodilator capacity and microvascular function. (Vaccarino et al.,2009; PMID: 19822823)
No. of Studies (Positive/Negative)	1 (1/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
coronary flow reserve	Vaccarino, 2009	patients and normal controls	Among the dizygotic twin pairs discordant for MDD, the CFR was 14% lower in the twins with MDD than in their brothers without MDD (2.36 vs 2.74) (P = .03). This association was not present in the monozygotic discordant pairs who were genetically matched (2.86 vs 2.64) (P = .19). The zygosity-MDD interaction after adjustment was significant (P = .006). The CFR in the dizygotic twins with MDD was also lower than in the control twins.	Among the dizygotic twin pairs discordant for MDD, the CFR w...... Among the dizygotic twin pairs discordant for MDD, the CFR was 14% lower in the twins with MDD than in their brothers without MDD (2.36 vs 2.74) (P = .03). This association was not present in the monozygotic discordant pairs who were genetically matched (2.86 vs 2.64) (P = .19). The zygosity-MDD interaction after adjustment was significant (P = .006). The CFR in the dizygotic twins with MDD was also lower than in the control twins. More...

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Note:
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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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