Signs Report

Name	Cardiac vagal control (CVC)
Description	Cardiac vagal control (CVC) is a physiological marker that has been implicated in emotion regulation. Because activity in the vagus nerve is an important source of beat-to-beat changes in heart rate, it is possible to assess CVC indirectly by taking electrocardiogram measures of high-frequency variability in cardiac interbeat intervals. These high-frequency oscillations in cardiac interbeat interval are related to the respiratory cycle and are thus commonly referred to as respiratory sinus arrhythmia (RSA). Significant evidence supports the idea that low levels of resting CVC, as indexed by RSA, are associated with impaired self-regulation in child and adult populations. Low levels of resting CVC have been investigated in cross-sectional and longitudinal studies as risk factors for several adult psychiatric disorders, including Major Depressive Disorder (MDD).
No. of Studies (Positive/Negative)	1 (1/0)

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
cardiac vagal control (CVC)		Sleep disturbances(insomnia)	symptoms	Rottenberg, 2007	patients only		In symptom-specific analyses, resting CVC was positively rel...... In symptom-specific analyses, resting CVC was positively related to sad mood and crying and inversely related to middle and late insomnia. More...
cardiac vagal control (CVC)		Depressed mood(sad mood)	symptoms	Rottenberg, 2007	patients only		In symptom-specific analyses, resting CVC was positively rel...... In symptom-specific analyses, resting CVC was positively related to sad mood and crying and inversely related to middle and late insomnia. More...

---

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web