Gene Report

Basic Information

Approved Symbol	CADM2
Approved Name	cell adhesion molecule 2
Previous Symbol	IGSF4D
Previous Name	"immunoglobulin superfamily, member 4D"
Symbol Alias	NECL3, Necl-3, SynCAM2
Name Alias	"nectin-like 3"
Location	3p12.2
Position	chr3:86115934-86123579 (+)
External Links	Entrez Gene: 253559 Ensembl: ENSG00000175161 UCSC: uc003dqj.3 HGNC ID: 29849
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between CADM2 and MDD (count: 0)

Positive relationships between CADM2 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
Cadm2		Histone-lysine N-methyltransferase SETDB1(Setdb1 (Set domain, bifurcated 1))	protein	Jiang Y, 2010	animal model		Gene was occupied by Setdb1 in neuron Gene was occupied by Setdb1 in neuron

Positive relationship network of CADM2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CADM2 and MDD (count: 0)

Negative relationships between CADM2 and other components at different levels (count: 0)

CADM2 related SNPs in MK4MDD (count: 0)

CADM2 related proteins in MK4MDD (count: 0)

CADM2 related GO terms (count: 15)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0045216	cell-cell junction organization	biological process	TAS

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0034332	adherens junction organization	biological process	TAS
GO:0008037	cell recognition	biological process	IBA
GO:0034329	cell junction assembly	biological process	TAS
GO:0042803	protein homodimerization activity	molecular function	IBA
GO:0030424	axon	cellular component	IEA
GO:0005913	cell-cell adherens junction	cellular component	IBA
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	biological process	IBA
GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	biological process	IBA
GO:0005887	integral component of plasma membrane	cellular component	IBA
GO:0005886	plasma membrane	cellular component	TAS
GO:0005102	receptor binding	molecular function	IBA
GO:0045202	synapse	cellular component	IEA
GO:0004872	receptor activity	molecular function	IBA
GO:0050839	cell adhesion molecule binding	molecular function	IBA

CADM2 related KEGG pathways (count: 0)

CADM2 related BioCarta pathways (count: 0)

CADM2 related Reactome pathways (count: 3)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19331	cell cell_adhesion_systems	Epithelial cell-cell contacts consist of three major adhesio...... Epithelial cell-cell contacts consist of three major adhesion systems: adherens junctions. TJs form physical barriers in various tissues and regulate paracellular transport of water, ions, and small water soluble molecules. Desmosomes mediate strong cell adhesion linking the intermediate filament cytoskeletons between cells and playing roles in wound repair, tissue morphogenesis, and cell signaling. Desmosomes will be covered in a later Reactome release. More...
REACT_20676	cell junction_organization
REACT_19195	adherens junctions_interactions	The adherens junctions. The molecular constituents of adhere...... The adherens junctions. The molecular constituents of adherens junctions form adhesive units which are organized into higher order junctional adhesions that create a zipper-like seal between adjacent cells. Junctional adhesions function in epithelial cell polarization and in the coupling of cytoskeletons in adjacent cells that allow coordinated movements. During embryonic development, AJs function in specifying adhesion between cells and contribute in the sorting of different cell types. AJs also regulate cell polarity and shape, promote cell-cell communication and help mediate contact inhibition of cell growth. This module covers transdimerization events involving AJ transmembrane proteins. More...

CADM2 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped Reactome pathways