Genomic Region Report

Region Name	12q22-q23.2
Location	12:92600000-103800000
No. of Studies (Positive/Negative)	1(1/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
12q22-q23.2	Abkevich, 2003	patients and normal controls	P-value=0.0000007	We identified significant linkage to major depression in mal...... We identified significant linkage to major depression in males at marker D12S1300 (multipoint heterogeneity LOD score 4.6; P=.00003 after adjustment for multiple testing). With additional markers, the linkage evidence became highly significant, with the multipoint heterogeneity LOD score at marker D12S1706 increasing to 6.1 (P=.0000007 after adjustment for multiple testing). This study confirms the presence of one or more genes involved in psychiatric diseases on the q arm of chromosome 12 and provides strong evidence for the existence of a sex-specific predisposition gene to major depression at 12q22-q23.2. More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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