MK4MDD

SNP Report

Basic Information
Name rs579702 dbSNP Ensembl
Location Chrchr6:108740248(Forward)
Variant Alleles T/C
Ancestral Allele C
No. of Studies (Positive/Negative) 1 (1/0) Help

Positive relationship between rs579702 and MDD (count: 1)
Reference Research Type Statistical Result Relation Description Help
Kopczak, 2015 Patients and nomal controls p=0.002 The polymorphisms showing the highest nominal associations w...... The polymorphisms showing the highest nominal associations with major depression and treatment response were located in the IGF1R gene on chromosome 15 (rs4966044, p=0.003) and in in the FOXO3 region on chromosome 6 (rs579702, p=0.002), respectively. Interestingly, three SNPs located in the FOXO3 region were nominally associated with disease susceptibility as well as antidepressant treatment response: rs17069826, rs17069835, and rs578889 (see Supplementary Tables 1 and 2). The polymorphisms reported in the genome-wide study for IGF-I levels (Wang et al., 2014) showed no significant association with major depression or treatment response in our analyses and thus could not be directly linked to these depression phenotypes. More...

Relationships between rs579702 and other components at different levels (count: 0) Help
Positive relationship network of rs579702 in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between rs579702 and MDD (count: 0)
Negative relationships between rs579702 and other components at different levels (count: 0) Help
rs579702 related genes (count: 0)