MK4MDD

SNP Report

Basic Information
Name rs16856199 dbSNP Ensembl
Location Chrchr1:232018366(Forward)
Variant Alleles T/A
Ancestral Allele T
No. of Studies (Positive/Negative) 1 (1/0) Help

Positive relationship between rs16856199 and MDD (count: 1)
Reference Research Type Statistical Result Relation Description Help
Thomson PA, 2013 patients and normal controls We report 2718 validated single-nucleotide polymorphisms (SN...... We report 2718 validated single-nucleotide polymorphisms (SNPs) of which 2010 have a minor allele frequency of <1%. Only 38% of these variants are reported in the 1000 Genomes Project European subset. This suggests that many DISC1 SNPs remain undiscovered and are essentially private. Rare coding variants identified exclusively in patients were found in likely functional protein domains. Significant region-wide association was observed between rs16856199 and rMDD (P=0.026, unadjusted P=6.3 x 10-5, OR=3.48). This was not replicated in additional recurrent major depression samples (replication P=0.11). Combined analysis of both the original and replication set supported the original association (P=0.0058, OR=1.46). More...

Relationships between rs16856199 and other components at different levels (count: 0) Help
Positive relationship network of rs16856199 in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between rs16856199 and MDD (count: 0)
Negative relationships between rs16856199 and other components at different levels (count: 0) Help
rs16856199 related genes (count: 0)