MK4MDD

Pathway Report

Basic Information
Name histone-lysine N-methyltransferase activity
GO Link ID: GO:0018024
Name: histone-lysine N-methyltransferase activity
Type: molecular function
Description "Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives."
No. of Studies (Positive/Negative) 1 (1/0) Help

Positive relationship between histone-lysine N-methyltransferase activity and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
histone-lysine N-methyltransferase activity Network and C, 2015 patients only FDR q-value=0.08282755 The degree of rank correlation between pathways across pairs...... The degree of rank correlation between pathways across pairs of disorders was significant (Supplementary Tables 4 and 6), with 49 pathways with combined q-value <0.1 spanning the three adult disorders (Table 2, Supplementary Table 7). Of these, 16 are significant at q < 0.05, with the top pathway (GO:51568: histone H3-K4 methylation) having a q = 0.0003 (Table 2). These results are more significant than those observed in any of the disorders analyzed alone. We then use multidimensional scaling (MDS) to cluster these sets in terms of shared genes. More...

Positive relationships between histone-lysine N-methyltransferase activity and other components at different levels (count: 0) Help
Positive relationship network of histone-lysine N-methyltransferase activity in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between histone-lysine N-methyltransferase activity and MDD (count: 0)
Negative relationships between histone-lysine N-methyltransferase activity and other components at different levels (count: 0) Help
Pathway histone-lysine N-methyltransferase activity related genes in MK4MDD (count: 2)