Name: histone-lysine N-methyltransferase activity
Type: molecular function
"Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives."
No. of Studies (Positive/Negative)
Positive relationship between histone-lysine N-methyltransferase activity and MDD (count: 1)
The degree of rank correlation between pathways across pairs......
The degree of rank correlation between pathways across pairs of disorders was significant (Supplementary Tables 4 and 6), with 49 pathways with combined q-value <0.1 spanning the three adult disorders (Table 2, Supplementary Table 7). Of these, 16 are significant at q < 0.05, with the top pathway (GO:51568: histone H3-K4 methylation) having a q = 0.0003 (Table 2). These results are more significant than those observed in any of the disorders analyzed alone. We then use multidimensional scaling (MDS) to cluster these sets in terms of shared genes.More...
Positive relationships between histone-lysine N-methyltransferase activity and other components at different levels (count: 0)
Positive relationship network of histone-lysine N-methyltransferase activity in MK4MDD
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Negative relationships between histone-lysine N-methyltransferase activity and MDD (count: 0)
Negative relationships between histone-lysine N-methyltransferase activity and other components at different levels (count: 0)
Pathway histone-lysine N-methyltransferase activity related genes in MK4MDD (count: 2)
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
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Last update: October 10, 2015