MK4MDD

Pathway Report

Basic Information
Name dendritic spine
GO Link ID: GO:0043197
Name: dendritic spine
Type: cellular component
Description "A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including ""thin"", ""stubby"", ""mushroom"", and ""branched"", with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. "
No. of Studies (Positive/Negative) 1 (1/0) Help

Positive relationship between dendritic spine and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
dendritic spine Network and C, 2015 patients only FDR q-value=0.08282755 The degree of rank correlation between pathways across pairs...... The degree of rank correlation between pathways across pairs of disorders was significant (Supplementary Tables 4 and 6), with 49 pathways with combined q-value <0.1 spanning the three adult disorders (Table 2, Supplementary Table 7). Of these, 16 are significant at q < 0.05, with the top pathway (GO:51568: histone H3-K4 methylation) having a q = 0.0003 (Table 2). These results are more significant than those observed in any of the disorders analyzed alone. We then use multidimensional scaling (MDS) to cluster these sets in terms of shared genes. More...

Positive relationships between dendritic spine and other components at different levels (count: 0) Help
Positive relationship network of dendritic spine in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between dendritic spine and MDD (count: 0)
Negative relationships between dendritic spine and other components at different levels (count: 0) Help
Pathway dendritic spine related genes in MK4MDD (count: 29)