MK4MDD

Pathway Report

Basic Information
Name Vascular smooth muscle contraction
KEGG Link ID: hsa04270
Name: vascular smooth_muscle_contraction
Brief Description: Vascular smooth muscle contraction
Full Description: The vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure. The principal mechanisms that regulate the contractile state of VSMCs are changes in cytosolic Ca2+ concentration (c). In response to vasoconstrictor stimuli, Ca2+ is mobilized from intracellular stores and/or the extracellular space to increase c in VSMCs. The increase in c, in turn, activates the Ca2+-CaM-MLCK pathway and stimulates MLC20 phosphorylation, leading to myosin-actin interactions and, hence, the development of contractile force. The sensitivity of contractile myofilaments or MLC20 phosphorylation to Ca2+ can be secondarily modulated by other signaling pathways. During receptor stimulation, the contractile force is greatly enhanced by the inhibition of myosin phosphatase. Rho/Rho kinase, PKC, and arachidonic acid have been proposed to play a pivotal role in this enhancement. The signaling events that mediate relaxation include the removal of a contractile agonist (passive relaxation) and activation of cyclic nucleotide-dependent signaling pathways in the continued presence of a contractile agonist (active relaxation). Active relaxation occurs through the inhibition of both Ca2+ mobilization and myofilament Ca2+ sensitivity in VSMCs.
No. of Studies (Positive/Negative) 1 (1/0) Help

Positive relationship between Vascular smooth muscle contraction and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
Vascular smooth muscle contraction Kao CF, 2012 patients and normal controls We found 17 significantly enriched pathways for depression We found 17 significantly enriched pathways for depression

Positive relationships between Vascular smooth muscle contraction and other components at different levels (count: 0) Help
Positive relationship network of Vascular smooth muscle contraction in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
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3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Vascular smooth muscle contraction and MDD (count: 0)
Negative relationships between Vascular smooth muscle contraction and other components at different levels (count: 0) Help
Pathway Vascular smooth muscle contraction related genes in MK4MDD (count: 21)