Gene Report

Basic Information

Approved Symbol	UBE2S
Approved Name	ubiquitin-conjugating enzyme E2S
Symbol Alias	E2-EPF
Name Alias	ubiquitin carrier protein, "ubiquitin-conjugating enzyme E2-24 kD", "ubiquitin-protein ligase"
Location	19q13.43
Position	chr19:55912650-55919325 (-)
External Links	Entrez Gene: 27338 Ensembl: ENSG00000108106 UCSC: uc002qkx.1 HGNC ID: 17895
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between UBE2S and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Ubiquitin-conjugating enzyme E2S	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between UBE2S and other components at different levels (count: 0)

Positive relationship network of UBE2S in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between UBE2S and MDD (count: 0)

Negative relationships between UBE2S and other components at different levels (count: 0)

UBE2S related SNPs in MK4MDD (count: 0)

UBE2S related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Ubiquitin-conjugating enzyme E2 S	Q16763	0(0/0)	Gene mapped

UBE2S related GO terms (count: 15)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0032553	ribonucleotide binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0044314	protein K27-linked ubiquitination	biological process	IDA
GO:0005680	anaphase-promoting complex	cellular component	IDA[19822757]
GO:0006464	cellular protein modification process	biological process	TAS[1379239]
GO:0070979	protein K11-linked ubiquitination	biological process	IDA
GO:0070534	protein K63-linked ubiquitination	biological process	IDA
GO:0035519	protein K29-linked ubiquitination	biological process	IDA
GO:0085020	protein K6-linked ubiquitination	biological process	IDA
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	biological process	IDA[19822757]
GO:0010994	free ubiquitin chain polymerization	biological process	IDA[19822757]
GO:0004842	ubiquitin-protein ligase activity	molecular function	IDA; IDA[19822757]
GO:0005524	ATP binding	molecular function	IEA
GO:0051488	activation of anaphase-promoting complex activity	biological process	IDA[19822757]
GO:0051301	cell division	biological process	IEA
GO:0010458	exit from mitosis	biological process	IDA[19820702]; IMP[19822757]

UBE2S related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04120	ubiquitin mediated_proteolysis	Ubiquitin mediated proteolysis	Protein ubiquitination plays an important role in eukaryotic...... Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates. More...

UBE2S related BioCarta pathways (count: 0)

UBE2S related Reactome pathways (count: 0)

UBE2S related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways