Gene Report

Basic Information

Approved Symbol	TUSC3
Approved Name	tumor suppressor candidate 3
Symbol Alias	MGC13453, N33, OST3A, MRT7
Name Alias	oligosaccharyltransferase 3 homolog A (S. cerevisiae)
Location	8p22
Position	chr8:15397596-15624158 (+)
External Links	Entrez Gene: 7991 Ensembl: ENSG00000104723 UCSC: uc003wwt.3 HGNC ID: 30242
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between TUSC3 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
TUSC3	Guilloux JP, 2012	patients and normal controls		genes significantly affected in female MDD subjects genes significantly affected in female MDD subjects

Positive relationships between TUSC3 and other components at different levels (count: 0)

Positive relationship network of TUSC3 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between TUSC3 and MDD (count: 0)

Negative relationships between TUSC3 and other components at different levels (count: 0)

TUSC3 related SNPs in MK4MDD (count: 0)

TUSC3 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Tumor suppressor candidate 3	Q13454	0(0/0)	Gene mapped

TUSC3 related GO terms (count: 13)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0044267	cellular protein metabolic process	biological process	TAS
GO:0015095	magnesium ion transmembrane transporter activity	molecular function	IMP[19717468]
GO:0045454	cell redox homeostasis	biological process	IEA
GO:0050890	cognition	biological process	IMP[18455129]
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	molecular function	ISS
GO:0008250	oligosaccharyltransferase complex	cellular component	IDA[15835887]
GO:0006487	protein N-linked glycosylation	biological process	NAS[18455129]
GO:0015693	magnesium ion transport	biological process	IGI[19717468]; IGI[19717468]; IMP[19717468]
GO:0005887	integral to plasma membrane	cellular component	NAS[19717468]
GO:0005739	mitochondrion	cellular component	ISS
GO:0005789	endoplasmic reticulum membrane	cellular component	TAS
GO:0018279	protein N-linked glycosylation via asparagine	biological process	ISS; TAS
GO:0043687	post-translational protein modification	biological process	TAS

TUSC3 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa00510	n glycan_biosynthesis	N-Glycan biosynthesis	N-glycans or asparagine-linked glycans are major constituent...... N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glycosidic bond, GlcNAc b1- Asn. Biosynthesis of N-glycans begins on the cytoplasmic face of the ER membrane with the transferase reaction of UDP-GlcNAc and the lipid-like precursor P-Dol (dolichol phosphate) to generate GlcNAc a1- PP-Dol. After sequential addition of monosaccharides by ALG glycosyltransferases, the N-glycan precursor is attached by the OST (oligosaccharyltransferase) complex to the polypeptide chain that is being synthesized and translocated through the ER membrane. The protein-bound N-glycan precursor is subsequently trimmed, extended, and modified in the ER and Golgi by a complex series of reactions catalyzed by membrane-bound glycosidases and glycosyltransferases. N-glycans thus synthesized are classified into three types: high-mannose type, complex type, and hybrid type. Defects in N-glycan biosynthesis lead to a variety of human diseases known as congenital disorders of glycosylation. More...

TUSC3 related BioCarta pathways (count: 0)

TUSC3 related Reactome pathways (count: 0)

TUSC3 related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways