Gene Report

Basic Information

Approved Symbol	TUBB4A
Approved Name	tubulin, beta 4A class IVa
Previous Symbol	TUBB4
Previous Name	tubulin, beta 4, "tubulin, beta 4 class IVa"
Symbol Alias	beta-5
Name Alias	class IVa beta-tubulin
Location	19p13.3
Position	chr19:6494330-6502330 (-)
External Links	Entrez Gene: 10382 Ensembl: ENSG00000104833 UCSC: uc002mfg.1 HGNC ID: 20774
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between TUBB4A and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
TUBB4	Kang HJ, 2012	patients and normal controls		Here we use microarray gene profiling and electron microscop...... Here we use microarray gene profiling and electron microscopic stereology to reveal lower expression of synaptic-function-related genes (CALM2, SYN1, RAB3A, RAB4B and TUBB4) in the dlPFC of subjects with MDD and a corresponding lower number of synapses. We also identify a transcriptional repressor, GATA1, expression of which is higher in MDD More...

Positive relationships between TUBB4A and other components at different levels (count: 0)

Positive relationship network of TUBB4A in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between TUBB4A and MDD (count: 0)

Negative relationships between TUBB4A and other components at different levels (count: 0)

TUBB4A related SNPs in MK4MDD (count: 0)

TUBB4A related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Tubulin beta-4A chain	P04350	0(0/0)	Gene mapped

TUBB4A related GO terms (count: 20)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0003924	GTPase activity	molecular function	IEA
GO:0005874	microtubule	cellular component	IDA
GO:0044267	cellular protein metabolic process	biological process	TAS
GO:0015630	microtubule cytoskeleton	cellular component	IDA
GO:0033269	internode region of axon	cellular component	IEA
GO:0005198	structural molecule activity	molecular function	IEA
GO:0043025	neuronal cell body	cellular component	IEA
GO:0043209	myelin sheath	cellular component	IEA
GO:0005829	cytosol	cellular component	TAS
GO:0005515	protein binding	molecular function	IPI
GO:0000086	G2/M transition of mitotic cell cycle	biological process	TAS
GO:0051258	protein polymerization	biological process	IEA
GO:0006457	protein folding	biological process	TAS
GO:0007018	microtubule-based movement	biological process	IEA
GO:0000278	mitotic cell cycle	biological process	TAS
GO:0005886	plasma membrane	cellular component	IDA
GO:0005525	GTP binding	molecular function	IEA
GO:0005737	cytoplasm	cellular component	IDA
GO:0005929	cilium	cellular component	IEA
GO:0051084	'de novo' posttranslational protein folding	biological process	TAS

TUBB4A related KEGG pathways (count: 0)

TUBB4A related BioCarta pathways (count: 0)

TUBB4A related Reactome pathways (count: 0)

TUBB4A related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms