MK4MDD

Protein Report

Basic Information
Protein Name Synaptic vesicular amine transporter
UniPortKB Q05940
No. of Studies (Positive/Negative) 2 (2/0) Help
Type Literature-origin
Positive relationship between Synaptic vesicular amine transporter and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description Help
vesicular monoamine transporter (VMAT2) Zucker, 2002 patients and normal controls A significant elevation in the VMAT2 density (B(max)) was ob...... A significant elevation in the VMAT2 density (B(max)) was observed in the platelets of untreated MDD patients (+24%) compared to healthy control subjects. More...
VMAT2 Iritani, 2006 animal model The results showed more VMAT2-immunoreactive varicose fibers...... The results showed more VMAT2-immunoreactive varicose fibers in the pyramidal cell layer of hippocampus and parahippocampal cortexes, and more intense 5HTT-immunoreactivity in the pyramidal cell layer and the area CA4 of hippocampus in the animal models of depression compared to those of the controls. On the other hand, lower density of 5HT1a-immunoreactive deposits in the pyramidal cell layer of hippocampus and the parahippocampal cortex was observed in the animal models of depression compared to those of the controls. More...

Positive relationships between Synaptic vesicular amine transporter and other components at different levels (count: 0) Help
Positive relationship network of Synaptic vesicular amine transporter in MK4MDD
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network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Synaptic vesicular amine transporter and MDD (count: 0)
Negative relationships between Synaptic vesicular amine transporter and other components at different levels (count: 0) Help
Related Gene Info
Gene Symbol Gene Name Type No. of Studies (Positive/Negative) Add to Relationship Set
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 Literature-origin; Protein mapped 1 (1/0)