Gene Report

Basic Information

Approved Symbol	SLC4A1
Approved Name	solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
Previous Symbol	EPB3, AE1, DI, WD
Previous Name	"Waldner blood group", "erythrocyte membrane protein band 3", "Diego blood group", "solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)", "solute carrier family 4 (anion exchanger), member 1"
Symbol Alias	RTA1A, CD233, FR, SW, WR
Name Alias	"Froese blood group", "Swann blood group", "Wright blood group"
Location	17q21.31
Position	chr17:42351646-42351654 (-)
External Links	Entrez Gene: 6521 Ensembl: ENSG00000004939 UCSC: uc002igf.4 HGNC ID: 11027
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SLC4A1 and MDD (count: 0)

Positive relationships between SLC4A1 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
SLC4A1		anxiety disorder(anxiety disorder)	symptoms	Redei, 2015	Patients and nomal controls	effect-size=-0.88	On the basis of the hypothesis that chronic stress markers, ...... On the basis of the hypothesis that chronic stress markers, such as those developed from our CRS model, might also track anxiety-like states, we evaluated the possibility of differential expression of the transcript panel between those who were diagnosed with MDD with or without a comorbid anxiety disorder. This intragroup analysis revealed medium-to-large effect-size differences in 18 of the 26 candidate biomarkers.thus, the nonoverlapping candidates FAM46A, NAGA, TLR7, ZNF291/SCAPER, AHSP DGKA, GCLM,GGA3, IRF3, KIAA1539,and SLC4A1 are specific to MDDcomorbidwith anxiety.Theoverlapping transcripts CD59,IGSF4A/CADM1,AMFR,CAT,CDR2, CMAS,and PSME1 might represent transcriptomic alterations common to both major depression and anxiety disorders ormay represent a consistent alteration in EOMDD patients with depression regardless of comorbidities. More...

Positive relationship network of SLC4A1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SLC4A1 and MDD (count: 0)

Negative relationships between SLC4A1 and other components at different levels (count: 0)

SLC4A1 related SNPs in MK4MDD (count: 0)

SLC4A1 related proteins in MK4MDD (count: 0)

SLC4A1 related GO terms (count: 28)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005886	plasma membrane	cellular component	TAS
GO:0055085	transmembrane transport	biological process	TAS
GO:0005515	protein binding	molecular function	IPI[16669616\|25012180\|26049106]
GO:0003779	actin binding	molecular function	IEA
GO:0072562	blood microparticle	cellular component	IDA[22516433]
GO:0015106	bicarbonate transmembrane transporter activity	molecular function	IDA[24121512]
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0015108	chloride transmembrane transporter activity	molecular function	ISS
GO:0006820	anion transport	biological process	IDA[14734552]
GO:0006811	ion transport	biological process	TAS
GO:0016021	integral component of membrane	cellular component	NAS[1527044]
GO:0008022	protein C-terminus binding	molecular function	IEA
GO:0005887	integral component of plasma membrane	cellular component	IDA[379653\|24121512]
GO:0005452	inorganic anion exchanger activity	molecular function	IDA[24121512]; TAS
GO:0030018	Z disc	cellular component	ISS
GO:0042803	protein homodimerization activity	molecular function	IPI[379653]
GO:0030506	ankyrin binding	molecular function	IPI[379653]
GO:1902476	chloride transmembrane transport	biological process	IBA
GO:0019899	enzyme binding	molecular function	IEA
GO:0008509	anion transmembrane transporter activity	molecular function	TAS[4027230]
GO:0043495	protein anchor	molecular function	TAS[10950304]
GO:0016323	basolateral plasma membrane	cellular component	IDA[12539048\|14734552]
GO:0015301	anion:anion antiporter activity	molecular function	IDA[14734552]
GO:0006821	chloride transport	biological process	ISS
GO:0015701	bicarbonate transport	biological process	IDA[24121512]; TAS
GO:0006873	cellular ion homeostasis	biological process	TAS[8841202]
GO:0030863	cortical cytoskeleton	cellular component	IDA[16669616]
GO:0070062	extracellular exosome	cellular component	IDA[19056867]

SLC4A1 related KEGG pathways (count: 0)

SLC4A1 related BioCarta pathways (count: 0)

SLC4A1 related Reactome pathways (count: 3)

ID	Name	Description
Gene mapped Reactome pathways
REACT_15518	transmembrane transport_of_small_molecules
REACT_19118	slc mediated_transmembrane_transport	Proteins with transporting functions can be roughly classifi...... Proteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the movement of the substrates across the membrane, against their electrochemical gradient. Channels at the open state can transfer the substrates. At least 20-25% amino-acid sequence identity is shared by members belonging to the same SLC family. No homology is shared between different SLC families. While the HUGO nomenclature system by definition only includes human genes, the nomenclature system has been informally extended to include rodent species through the use of lower cases letters (e.g., Slc1a1 denotes the rodent ortholog of the human SLC1A1 gene). And it's worthwhile to mention that pumps, channels and aquporins are not included in SLC superfamily. More...
REACT_19397	inorganic cation_anion_slc_transporters	Teleologically, one might argue that inorganic cation and an...... Teleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively inorganic cations and anions across membranes : SLC4 plays a pivotal role in mediating Na+- and/or Cl-dependent transport of basic anions [e.g. HCO3, ; SLC8 is a group of Na+/Ca2+ exchangers ; SLC24 is a group of Na+/Ca2+ or Na+/K+ exchangers ; SLC9 comprises Na+/H+ exchanger proteins involved in the electroneutral exchange of sodium ion and protons ; SLC12 functions as Na+, K+ and Cl ion electroneutral symporters ; SLC26 is the trans-epithelial multifunctional anion. SLC34 is an important Type II Na+/; SLC20 was originally identified as a viral receptor, and functions as a Type III Na+/. Eight SLC gene families are involved in the transport of amino acids and oligopeptides. More...

SLC4A1 related interactors from protein-protein interaction data in HPRD (count: 13)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SLC4A1	SYK	No	in vitro;in vivo	1998697 , 2065070 , 10942405 , 16118313
SLC4A1	ANK1	No	in vitro	6449514
SLC4A1	LYN	No	in vitro;in vivo	1998697 , 2065070 , 10942405 , 16118313
SLC4A1	CA4	No	in vitro	11994299
SLC4A1	SLC4A1AP	No	in vitro;in vivo;yeast 2-hybrid	9422766 , 11934690
SLC4A1	ACTC1	No	in vivo;yeast 2-hybrid	12898519
SLC4A1	CDKN2A	No	in vitro;in vivo;yeast 2-hybrid	15811326
SLC4A1	CANX	No	in vitro;in vivo	10364201
SLC4A1	PLDN	No	in vitro	2968981
SLC4A1	CA2	No	in vitro	9774471 , 11063570 , 10820026
SLC4A1	SLC4A1	Yes	in vitro	11049968 , 7479704
SLC4A1	RHAG	No	in vivo	12531814
SLC4A1	EPB41	No	in vitro	1639060

Gene Report

Gene mapped GO terms

Gene mapped Reactome pathways