Gene Report

Basic Information

Approved Symbol	SEC24C
Approved Name	SEC24 family, member C (S. cerevisiae)
Previous Name	SEC24 (S. cerevisiae) related gene family, member C
Symbol Alias	KIAA0079
Location	10q22
Position	chr10:75504131-75531933 (+)
External Links	Entrez Gene: 9632 Ensembl: ENSG00000176986 UCSC: uc001jux.3 HGNC ID: 10705
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SEC24C and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
SEC24-related protein C	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between SEC24C and other components at different levels (count: 0)

Positive relationship network of SEC24C in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SEC24C and MDD (count: 0)

Negative relationships between SEC24C and other components at different levels (count: 0)

SEC24C related SNPs in MK4MDD (count: 0)

SEC24C related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Protein transport protein Sec24C	P53992	0(0/0)	Gene mapped

SEC24C related GO terms (count: 21)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005789	endoplasmic reticulum membrane	cellular component	TAS
GO:0048471	perinuclear region of cytoplasm	cellular component	IEA
GO:0043687	post-translational protein modification	biological process	TAS
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA
GO:0016044	cellular membrane organization	biological process	TAS
GO:0003674	molecular_function	molecular function	ND
GO:0012507	ER to Golgi transport vesicle membrane	cellular component	TAS
GO:0005634	nucleus	cellular component	IDA
GO:0030127	COPII vesicle coat	cellular component	NAS[10214955]
GO:0006888	ER to Golgi vesicle-mediated transport	biological process	NAS[10329445]; TAS
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	biological process	TAS
GO:0000139	Golgi membrane	cellular component	IEA
GO:0048208	COPII vesicle coating	biological process	TAS
GO:0005829	cytosol	cellular component	TAS
GO:0005515	protein binding	molecular function	IPI[18692470]
GO:0044267	cellular protein metabolic process	biological process	TAS
GO:0008270	zinc ion binding	molecular function	IEA
GO:0005730	nucleolus	cellular component	IDA
GO:0006886	intracellular protein transport	biological process	IEA
GO:0018279	protein N-linked glycosylation via asparagine	biological process	TAS
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	biological process	TAS

SEC24C related KEGG pathways (count: 0)

SEC24C related BioCarta pathways (count: 0)

SEC24C related Reactome pathways (count: 1)

ID	Name	Description
Gene mapped Reactome pathways
REACT_11123	membrane trafficking	The secretory membrane system allows a cell to regulate deli...... The secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is made up of distinct organelles, including the endoplasmic reticulum (ER), Golgi complex, plasma membrane, and tubulovesicular transport intermediates. These organelles mediate intracellular membrane transport between themselves and the cell surface. Membrane traffic within this system flows along highly organized directional routes. Secretory cargo is synthesized and assembled in the ER and then transported to the Golgi complex for further processing and maturation. Upon arrival at the trans Golgi network (TGN), the cargo is sorted and packaged into post-Golgi carriers that move through the cytoplasm to fuse with the cell surface. This directional membrane flow is balanced by retrieval pathways that bring membrane and selected proteins back to the compartment of origin. More...

SEC24C related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SEC24C	SEC23B	No	yeast 2-hybrid	16189514
SEC24C	SEC23A	No	in vitro;in vivo;yeast 2-hybrid	10075675

Gene Report

Gene mapped GO terms

Gene mapped Reactome pathways