MK4MDD

Brain Morphology and Function Report

Basic Information
Name Raphe nuclei
Brain Morphology The raphe nuclei are a moderate-size cluster of nuclei found in the brain stem.
Brain Function "Their main function is to release serotonin to the rest of the brain. Selective serotonin reuptake inhibitor (SSRI) antidepressants are believed to act in these nuclei, as well as at their targets."
Picture Raphe nuclei Source Magnify
No. of Studies (Positive/Negative) 3(2/1) Help

Positive relationships between Raphe nuclei and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description Help
median raphe nucleus Bach-Mizrachi, 2006 patients and normal controls 33% higher in the DRN and 17% higher in the MRN TPH2 expression is 33% higher in the DRN and 17% higher in t...... TPH2 expression is 33% higher in the DRN and 17% higher in the MRN as compared to matched nonpsychiatric controls More...
dorsal raphe nuclei Lee, 2011 patients and normal controls Decreased gray matter concentration was found in MDD patient...... Decreased gray matter concentration was found in MDD patients in the bilateral amygdalae, hippocampi, fusiform gyri, lingual gyri, insular gyri, middle-superior temporal gyri, thalami, cingulate gyri, the central lobule of the cerebellum, and the midbrain encompassing the dorsal raphe nuclei (DRN) More...

Positive relationships between Raphe nuclei and other components at different levels (count: 0) Help
Positive relationship network of Raphe nuclei in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Raphe nuclei and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
raphe nuclei Ordway, 2003 patients and normal controls No significant differences were observed in p-[125I]iodoclon...... No significant differences were observed in p-[125I]iodoclonidine binding to alpha2-adrenoceptors in the raphe nuclei comparing MD and control subjects. More...

Negative relationships between Raphe nuclei and other components at different levels (count: 0) Help