Gene Report

Basic Information

Approved Symbol	RPH3A
Approved Name	rabphilin 3A homolog (mouse)
Symbol Alias	KIAA0985, rabphilin, exophilin-1
Location	12q24.13
Position	chr12:113229549-113336686 (+)
External Links	Entrez Gene: 22895 Ensembl: ENSG00000089169 UCSC: uc001ttz.3 HGNC ID: 17056
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin; Protein mapped

Positive relationships between RPH3A and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
RPH3A	Sibille E, 2009	animal model; patients and nomal controls	R=0.88, P-value<5E-6; y slope=1.14	Downregulated in MDD patients Downregulated in MDD patients

Positive relationships between RPH3A and other components at different levels (count: 0)

Positive relationship network of RPH3A in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between RPH3A and MDD (count: 0)

Negative relationships between RPH3A and other components at different levels (count: 0)

RPH3A related SNPs in MK4MDD (count: 0)

RPH3A related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Rabphilin-3A	Q9Y2J0	1(1/0)	Literature-origin

RPH3A related GO terms (count: 10)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0030054	cell junction	cellular component	IEA
GO:0008021	synaptic vesicle	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006886	intracellular protein transport	biological process	IEA
GO:0008270	zinc ion binding	molecular function	IEA
GO:0016020	membrane	cellular component	IEA
GO:0005215	transporter activity	molecular function	IEA
GO:0005509	calcium ion binding	molecular function	ISS
GO:0005515	protein binding	molecular function	IPI[11377421]
GO:0005544	calcium-dependent phospholipid binding	molecular function	ISS
GO:0017137	Rab GTPase binding	molecular function	IEA

RPH3A related KEGG pathways (count: 0)

RPH3A related BioCarta pathways (count: 0)

RPH3A related Reactome pathways (count: 0)

RPH3A related interactors from protein-protein interaction data in HPRD (count: 10)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
RPH3A	RAB27A	No	in vitro;in vivo	12578829
RPH3A	CASK	No	in vitro;in vivo;yeast 2-hybrid	11377421
RPH3A	NRXN1	No	in vitro	8901523
RPH3A	YWHAH	No	in vitro	12871946
RPH3A	RAB3A	Yes	in vitro;in vivo	12937130 , 10025402
RPH3A	ADD2	No	in vitro	7999065 , 7707875 , 9244430
RPH3A	RAB15	No	in vitro	12578829
RPH3A	RAB3B	No	in vitro	8636125
RPH3A	GCH1	No	in vivo	7802677
RPH3A	RAB8A	No	in vitro	12578829

Gene Report

Literature-origin GO terms

Gene mapped GO terms