Gene Report

Basic Information

Approved Symbol	RNASEH2B
Approved Name	ribonuclease H2, subunit B
Previous Symbol	DLEU8, AGS2
Previous Name	deleted in lymphocytic leukemia 8, "Aicardi-Goutieres syndrome 2"
Symbol Alias	FLJ11712
Location	13q14.3
Position	chr13:51483814-51544596 (+)
External Links	Entrez Gene: 79621 Ensembl: ENSG00000136104 UCSC: uc001vfa.4 HGNC ID: 25671
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between RNASEH2B and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Hypothetical protein FLJ11712	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between RNASEH2B and other components at different levels (count: 0)

Positive relationship network of RNASEH2B in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between RNASEH2B and MDD (count: 0)

Negative relationships between RNASEH2B and other components at different levels (count: 0)

RNASEH2B related SNPs in MK4MDD (count: 0)

RNASEH2B related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Ribonuclease H2 subunit B	Q5TBB1	0(0/0)	Gene mapped

RNASEH2B related GO terms (count: 4)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005634	nucleus	cellular component	IDA
GO:0032299	ribonuclease H2 complex	cellular component	IDA
GO:0005730	nucleolus	cellular component	IDA
GO:0006401	RNA catabolic process	biological process	IDA

RNASEH2B related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa03030	dna replication	DNA replication	A complex network of interacting proteins and enzymes is req...... A complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (DnaB or MCM complex) precedes the DNA synthetic machinery and unwinds the duplex parental DNA in cooperation with the SSB or RPA. On the leading strand, replication occurs continuously in a 5 to 3 direction, whereas on the lagging strand, DNA replication occurs discontinuously by synthesis and joining of short Okazaki fragments. In prokaryotes, the leading strand replication apparatus consists of a DNA polymerase (pol III core), a sliding clamp (beta), and a clamp loader (gamma delta complex). The DNA primase (DnaG) is needed to form RNA primers. Normally, during replication of the lagging-strand DNA template, an RNA primer is removed either by an RNase H or by the 5 to 3 exonuclease activity of DNA pol I, and the DNA ligase joins the Okazaki fragments. In eukaryotes, three DNA polymerases (alpha, delta, and epsilon) have been identified. DNA primase forms a permanent complex with DNA polymerase alpha. PCNA and RFC function as a clamp and a clamp loader. FEN 1 and RNase H1 remove the RNA from the Okazaki fragments and DNA ligase I joins the DNA. More...

RNASEH2B related BioCarta pathways (count: 0)

RNASEH2B related Reactome pathways (count: 0)

RNASEH2B related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways