Gene Report

Basic Information

Approved Symbol	REST
Approved Name	RE1-silencing transcription factor
Symbol Alias	NRSF, XBR
Location	4q12
Position	chr4:57774042-57802010 (+)
External Links	Entrez Gene: 5978 Ensembl: ENSG00000084093 UCSC: uc003hci.3 HGNC ID: 9966
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between REST and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
REST	Goswami, 2010	patients and normal controls		We found that mRNA concentrations of the 5-HT1D receptor and...... We found that mRNA concentrations of the 5-HT1D receptor and the transcription factors, NUDR and REST, were significantly increased in DR-captured neurons of female MDD subjects compared to female control subjects More...

Positive relationships between REST and other components at different levels (count: 0)

Positive relationship network of REST in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between REST and MDD (count: 0)

Negative relationships between REST and other components at different levels (count: 0)

REST related SNPs in MK4MDD (count: 0)

REST related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
RE1-silencing transcription factor	Q13127	0(0/0)	Gene mapped

REST related GO terms (count: 38)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005515	protein binding	molecular function	IPI[12192000]
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	IMP
GO:0015271	outward rectifier potassium channel activity	molecular function	IMP[18570921]
GO:0032348	negative regulation of aldosterone biosynthetic process	biological process	IMP[19342457]
GO:0008270	zinc ion binding	molecular function	IEA
GO:0035690	cellular response to drug	biological process	IMP
GO:0001047	core promoter binding	molecular function	IDA[17984088]
GO:0005730	nucleolus	cellular component	IDA
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	molecular function	IDA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA; TAS[7697725]
GO:0045892	negative regulation of transcription, DNA-dependent	biological process	IDA[17984088]; IMP[18570921]; NAS[7871435]
GO:0003682	chromatin binding	molecular function	ISS
GO:0046676	negative regulation of insulin secretion	biological process	IMP
GO:2000798	negative regulation of amniotic stem cell differentiation	biological process	IMP
GO:0045665	negative regulation of neuron differentiation	biological process	IMP[18570921]
GO:2000740	negative regulation of mesenchymal stem cell differentiation	biological process	IMP[18570921]
GO:0008285	negative regulation of cell proliferation	biological process	IMP
GO:2000706	negative regulation of dense core granule biogenesis	biological process	ISS
GO:0050768	negative regulation of neurogenesis	biological process	ISS
GO:0043922	negative regulation by host of viral transcription	biological process	IDA[17555596]
GO:0001046	core promoter sequence-specific DNA binding	molecular function	IDA[8568247]
GO:0005634	nucleus	cellular component	IDA; NAS[7871435]
GO:0005737	cytoplasm	cellular component	IDA
GO:0045893	positive regulation of transcription, DNA-dependent	biological process	IDA[17984088]
GO:0071385	cellular response to glucocorticoid stimulus	biological process	IDA[17984088]
GO:0060379	cardiac muscle cell myoblast differentiation	biological process	ISS
GO:0045955	negative regulation of calcium ion-dependent exocytosis	biological process	ISS
GO:0005829	cytosol	cellular component	IEA
GO:2000065	negative regulation of cortisol biosynthetic process	biological process	IMP[19342457]
GO:0008134	transcription factor binding	molecular function	IPI[17130167]
GO:0070933	histone H4 deacetylation	biological process	IDA[17555596]
GO:0010629	negative regulation of gene expression	biological process	IMP
GO:0044212	transcription regulatory region DNA binding	molecular function	IDA[17555596]
GO:0017053	transcriptional repressor complex	cellular component	IDA[10734093]
GO:0043065	positive regulation of apoptotic process	biological process	IMP
GO:0071257	cellular response to electrical stimulus	biological process	IMP[18570921]
GO:0006355	regulation of transcription, DNA-dependent	biological process	NAS[7871435]
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IDA[19342457]

REST related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa05016	huntingtons disease	Huntington's disease	Huntington disease (HD) is an autosomal-dominant neurodegene...... Huntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). HD is caused by a CAG repeat expansion in the IT15 gene, which results in a long stretch of polyglutamine close to the amino-terminus of the HD protein huntingtin (Htt). Mutant Htt (mHtt) has effects both in the cytoplasm and in the nucleus. In the cytoplasm, full-length mHtt can interfere with BDNF vesicular transport on microtubules. This mutant protein also may lead to abnormal endocytosis and secretion in neurons, because normal Htt form a complex with the proteins Hip1, clathrin and AP2 that are involved in endocytosis. In addition, mHtt affects Ca2+ signaling by sensitizing InsP3R1 to activation by InsP3, stimulating NR2B/NR1 NMDAR activity, and destabilizing mitochondrial Ca2+ handling. As a result, stimulation of glutamate receptors leads to supranormal Ca2+ responses in HD MSN and mitochondrial Ca2+ overload. The mHtt translocates to the nucleus, where it forms intranuclear inclusions, though they are not primarily responsible for toxicity. Nuclear toxicity is believed to be caused by interference with gene transcription, leading to loss of transcription of neuroprotective molecules such as BDNF. While mHtt binds to p53 and upregulates levels of nuclear p53 as well as p53 transcriptional activity. Augmented p53 mediates mitochondrial dysfunction. More...

REST related BioCarta pathways (count: 0)

REST related Reactome pathways (count: 0)

REST related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
REST	SIN3B	No	in vitro;in vivo;yeast 2-hybrid	10570134
REST	HTT	No	in vivo	12881722
REST	RCOR1	No	in vitro;in vivo;yeast 2-hybrid	10449787

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways