Gene Report

Basic Information

Approved Symbol	RASGRP1
Approved Name	RAS guanyl releasing protein 1 (calcium and DAG-regulated)
Symbol Alias	CalDAG-GEFII, RASGRP
Location	15q15
Position	chr15:38857503-38857661 (-)
External Links	Entrez Gene: 10125 Ensembl: ENSG00000172575 UCSC: uc001zke.4 HGNC ID: 9878
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between RASGRP1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
RASGRP1	Jansen R, 2015	patients and normal controls	P-value=0.0000436;FDR=0.0584;beta=-0.234	we found 129 genes (142 probesets) differentially expressed ...... we found 129 genes (142 probesets) differentially expressed between the control and current MDD groups (FDR<0.1) More...

Positive relationships between RASGRP1 and other components at different levels (count: 0)

Positive relationship network of RASGRP1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between RASGRP1 and MDD (count: 0)

Negative relationships between RASGRP1 and other components at different levels (count: 0)

RASGRP1 related SNPs in MK4MDD (count: 0)

RASGRP1 related proteins in MK4MDD (count: 0)

RASGRP1 related GO terms (count: 54)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0000165	MAPK cascade	biological process	TAS

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005085	guanyl-nucleotide exchange factor activity	molecular function	TAS
GO:0090630	activation of GTPase activity	biological process	IDA[10807788]; IMP[12845332]
GO:0005789	endoplasmic reticulum membrane	cellular component	IEA
GO:0001934	positive regulation of protein phosphorylation	biological process	IDA[21968647]; IMP[23908768]
GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	biological process	IEA
GO:0032760	positive regulation of tumor necrosis factor production	biological process	IMP[19933860]
GO:0007165	signal transduction	biological process	TAS[9789079]
GO:0016020	membrane	cellular component	TAS[9582122]
GO:0007411	axon guidance	biological process	TAS
GO:1902715	positive regulation of interferon-gamma secretion	biological process	IMP[19933860]
GO:1900744	regulation of p38MAPK cascade	biological process	IMP[19933860]
GO:0007596	blood coagulation	biological process	TAS
GO:0008289	lipid binding	molecular function	TAS[9582122]
GO:0051259	protein oligomerization	biological process	IMP[23908768]
GO:0000186	activation of MAPKK activity	biological process	TAS
GO:0038095	Fc-epsilon receptor signaling pathway	biological process	TAS
GO:0042629	mast cell granule	cellular component	IEA
GO:1900274	regulation of phospholipase C activity	biological process	IMP[19933860]
GO:0005794	Golgi apparatus	cellular component	IDA[21968647]
GO:0005088	Ras guanyl-nucleotide exchange factor activity	molecular function	IMP[23908768]
GO:0007264	small GTPase mediated signal transduction	biological process	TAS
GO:0070372	regulation of ERK1 and ERK2 cascade	biological process	IMP[23908768]
GO:0008286	insulin receptor signaling pathway	biological process	TAS
GO:0048010	vascular endothelial growth factor receptor signaling pathway	biological process	TAS
GO:0046330	positive regulation of JNK cascade	biological process	IMP[19933860]
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological process	IMP[19933860]
GO:0007173	epidermal growth factor receptor signaling pathway	biological process	TAS
GO:0043406	positive regulation of MAP kinase activity	biological process	IMP[15899849]
GO:0005886	plasma membrane	cellular component	TAS
GO:0007265	Ras protein signal transduction	biological process	TAS
GO:0032825	positive regulation of natural killer cell differentiation	biological process	IEA
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	biological process	IMP[19933860]
GO:0008543	fibroblast growth factor receptor signaling pathway	biological process	TAS
GO:0008270	zinc ion binding	molecular function	IMP[23908768]
GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	biological process	IMP[19933860]
GO:0031210	phosphatidylcholine binding	molecular function	IMP[23908768]
GO:0001816	cytokine production	biological process	IEA
GO:0045087	innate immune response	biological process	TAS
GO:0000139	Golgi membrane	cellular component	IEA
GO:0005829	cytosol	cellular component	TAS
GO:0033089	positive regulation of T cell differentiation in thymus	biological process	IEA
GO:0032252	secretory granule localization	biological process	IEA
GO:0042803	protein homodimerization activity	molecular function	IMP[23908768]
GO:0001786	phosphatidylserine binding	molecular function	IMP[23908768]
GO:0030168	platelet activation	biological process	TAS
GO:0002437	inflammatory response to antigenic stimulus	biological process	IEA
GO:0046579	positive regulation of Ras protein signal transduction	biological process	IMP[19933860]
GO:0019992	diacylglycerol binding	molecular function	IMP[23908768]
GO:0005509	calcium ion binding	molecular function	IMP[23908768]
GO:0043547	positive regulation of GTPase activity	biological process	IMP[23908768]
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS
GO:0043303	mast cell degranulation	biological process	IEA
GO:0047496	vesicle transport along microtubule	biological process	IEA

RASGRP1 related KEGG pathways (count: 2)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04010	mapk signaling_pathway	MAPK signaling pathway	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...
hsa04660	t cell_receptor_signaling_pathway	T cell receptor signaling pathway	Activation of T lymphocytes is a key event for an efficient ...... Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. Engagement of these receptors through the interaction with a foreign antigen associated with major histocompatibility complex molecules and CD28 counter-receptors B7.1/B7.2, respectively, results in a series of signaling cascades. These cascades comprise an array of protein-tyrosine kinases, phosphatases, GTP-binding proteins and adaptor proteins that regulate generic and specialised functions, leading to T-cell proliferation, cytokine production and differentiation into effector cells. More...

RASGRP1 related BioCarta pathways (count: 0)

RASGRP1 related Reactome pathways (count: 0)

RASGRP1 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
RASGRP1	DGKZ	No	in vitro;in vivo	11257115
RASGRP1	HRAS	No	in vitro	9582122

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways