MK4MDD

Brain Morphology and Function Report

Basic Information
Name Prefrontal cortex
Brain Morphology "The prefrontal cortex (PFC) is the anterior part of the frontal lobes of the brain, lying in front of the motor and premotor areas."
Brain Function "This brain region has been implicated in planning complex cognitive behaviors, personality expression, decision making and moderating correct social behavior. The basic activity of this brain region is considered to be orchestration of thoughts and actions in accordance with internal goals. The most typical psychological term for functions carried out by the prefrontal cortex area is executive function. "
Picture Prefrontal cortex From Wiki. Magnify
No. of Studies (Positive/Negative) 31(30/1) Help

Positive relationships between Prefrontal cortex and MDD (count: 22)
Name in Literature Reference Research Type Statistical Result Relation Description Help
prefrontal cortex Fu, 2004 patients and normal controls Over time, depressed subjects showed a negatively correlated...... Over time, depressed subjects showed a negatively correlated increase of dynamic range in the prefrontal cortex. More...
prefrontal cortex McCabe, 2009 patients and normal controls Patients had a diminished neural supralinearity response (th...... Patients had a diminished neural supralinearity response (the potentiation produced by simultaneous presentation of the sight and flavor of the stimuli) in the prefrontal cortex for both aversive and pleasant conditions. More...
prefrontal cortex Awata, 1998 patients and normal controls (patients with major depressive disorder in late life) compa...... (patients with major depressive disorder in late life) compared with 13 age-matched controls, relative rCBF(regional cerebral blood flow) was significantly decreased bilaterally in the prefrontal cortex More...
prefrontal cortex Pagani, 2004 patients and normal controls P<0.005 As compared to normal controls, MDD rCBF (regional cerebral ...... As compared to normal controls, MDD rCBF (regional cerebral blood flow) was relatively higher in bilaterally in prefrontal cortex (P<0.005) More...
prefrontal cortices Kano, 2004 patients and normal controls Binding (histamine H1 receptor (H(1)R) binding) potential va...... Binding (histamine H1 receptor (H(1)R) binding) potential values for [(11)C]-doxepin binding in the frontal and prefrontal cortices, and cingulate gyrus were significantly lower in the depressed patients than those in the normal control subjects. More...
prefrontal cortical regions Anderson, 2004 patients and normal controls Unlike healthy male subjects who have significant increases ...... Unlike healthy male subjects who have significant increases in rCMRglu in prefrontal and parietal cortical regions after receiving fenfluramine, depressed male subjects have no significant increases in rCMRglu. More...
prefrontal cortex Laifenfeld, 2005 patients and normal controls Levels of CAM-L1 and of phosphorylated CREB (pCREB) were inc...... Levels of CAM-L1 and of phosphorylated CREB (pCREB) were increased in the prefrontal cortex of the depressed group, while CAM-L1, laminin and pCREB were decreased in the parieto-occipital cortex. More...
prefrontal cortex Matsuo, 2005 patients and normal controls Activation of the prefrontal cortex during the cognitive tas...... Activation of the prefrontal cortex during the cognitive task was significantly less in patients as compared with controls More...
prefrontal cortex Hunter, 2006 patients only Decreases in prefrontal cordance during the placebo lead-in ...... Decreases in prefrontal cordance during the placebo lead-in period were associated with lower final Hamilton depression scale scores in subjects randomly assigned to medication. Prefrontal changes explained 19% of the variance in final Hamilton depression scale scores. More...
prefrontal cortex Gemar, 2007 patients only Participants showed decreased activation in prefrontal corte...... Participants showed decreased activation in prefrontal cortex similar to those reported for remitted, medicated patients undergoing mood challenge, as well as for acutely depressed patients who were medication free. More...
prefrontal region Fujimoto, 2008 patients only The 3D-SSP score map showed decreased relative metabolism in...... The 3D-SSP score map showed decreased relative metabolism in the prefontal region in both hemispheres in patients compared with controls. More...
prefrontal cortices Korb, 2008 patients and normal controls MDD subjects showed significantly elevated current density i...... MDD subjects showed significantly elevated current density in delta, theta, alpha, beta1, and beta2 frequency bands relative to controls in anterior cingulate and prefrontal cortices. More...
prefrontal cortices Strigo, 2008 patients and normal controls Subjects with MDD compared with healthy controls showed decr...... Subjects with MDD compared with healthy controls showed decreased activation in the prefrontal cortices during painful stimulation relative to nonpainful stimulation, More...
prefrontal cortex Friedel, 2009 patients and normal controls In healthy controls prefrontal (BA10) activation and BA10-am...... In healthy controls prefrontal (BA10) activation and BA10-amygdala coupling increased with the number of 5-HTT low-expression risk alleles, this effect was abolished, and even reversed, in patients with MDD. More...
prefrontal cortex Bermpohl, 2009 patients and normal controls Healthy individuals showed enhanced activation in the dorsom...... Healthy individuals showed enhanced activation in the dorsomedial prefrontal cortex and decreased activation in the dorsolateral prefrontal cortex during cued compared to uncued emotional picture perception. The group comparison revealed that these modulatory effects were significantly attenuated in depressed patients. More...
prefrontal areas Herwig, 2010 patients and normal controls Differences between healthy and depressed persons were found...... Differences between healthy and depressed persons were found particularly for medial and dorsolateral prefrontal and insular activations. More...
prefrontal gray matter volume Frodl, 2010 patients and normal controls Significantly smaller hippocampal white matter and prefronta...... Significantly smaller hippocampal white matter and prefrontal gray matter volume was observed in patients with MD compared to healthy controls. More...
prefrontal cortex Frodl, 2010 patients and normal controls Moreover, the left prefrontal cortex was smaller in patients...... Moreover, the left prefrontal cortex was smaller in patients, whereby childhood stress resulted in larger prefrontal volumes in those subjects carrying the non-risk L-allele, suggesting preventive effects. More...
prefrontal cortex Gawryluk, 2011 patients and normal controls The levels of reduced, oxidized, and total GSH were signific...... The levels of reduced, oxidized, and total GSH were significantly decreased in post-mortem prefrontal cortex of MDD patients compared to the control group More...
prefrontal cortex Erk, 2010 patients and normal controls Patients exhibited diminished prefrontal activation and redu...... Patients exhibited diminished prefrontal activation and reduced prefrontolimbic coupling during active regulation. More...
prefrontal cortex Deschwanden, 2011 patients and normal controls The postmortem study showed lower levels of mGluR5 protein e...... The postmortem study showed lower levels of mGluR5 protein expression in the prefrontal cortex (Brodmann's area 10) in the depression group relative to the comparison group, More...
prefrontal cortex Jin, 2011 patients and normal controls Our results showed that the topological properties of depres...... Our results showed that the topological properties of depressed adolescents' networks were significantly disrupted compared with HC. Dysregulation of brain regions were found in the dorsolateral, medial and inferior prefrontal cortex. More...

Positive relationships between Prefrontal cortex and other components at different levels (count: 14) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Prefrontal cortex in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Prefrontal cortex and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
prefrontal regions Bonte, 2001 patients and normal controls Other localizations in the left frontal and bilateral prefro...... Other localizations in the left frontal and bilateral prefrontal regions did not attain significance, but each localization contained statistically significant maxima (z scores). More...

Negative relationships between Prefrontal cortex and other components at different levels (count: 0) Help