Periaqueductal gray (PAG) is the gray matter located around the cerebral aqueduct within the tegmentum of the midbrain.
"It plays a role in the descending modulation of pain and in defensive behaviour. The ascending pain and temperature fibers of the spinothalamic tract also send information to the PAG via the spinomesencephalic tract (so-named because the fibers originate in the spine and terminate in the PAG, in the mesencephalon or midbrain)."
No. of Studies (Positive/Negative)
Positive relationships between Periaqueductal gray and MDD (count: 2)
The unipolar-depressives had elevated 5-HTT BP relative to b......
The unipolar-depressives had elevated 5-HTT BP relative to both BD (bipolar-depressives) and HC (healthy-controls) groups in the vicinity of the periaqueductal gray (PAG, 20%, 22%, respectively). More...
Subjects with MDD compared with healthy controls showed decr......
Subjects with MDD compared with healthy controls showed decreased activation in periaqueductal gray matter during painful stimulation relative to nonpainful stimulation,More...
Positive relationships between Periaqueductal gray and other components at different levels (count: 0)
Positive relationship network of Periaqueductal gray in MK4MDD
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1. The different color of the nodes denotes the level of the nodes.
Protein and Other Molecule
Cell and Molecular Pathway
Cognition and Behavior
Symptoms and Signs
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node.
Right-click will show also the menus to link to the report page of the node and remove the node and related edges.
Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web
Negative relationships between Periaqueductal gray and MDD (count: 0)
Negative relationships between Periaqueductal gray and other components at different levels (count: 0)
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
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Last update: October 10, 2015