Gene Report

Basic Information

Approved Symbol	PVRL1
Approved Name	poliovirus receptor-related 1 (herpesvirus entry mediator C)
Previous Symbol	HVEC, ED4
Symbol Alias	PRR, PRR1, PVRR1, SK-12, HIgR, CLPED1, CD111, OFC7
Name Alias	"nectin"
Location	11q23-q24
Position	chr11:119599264-119599435 (-)
External Links	Entrez Gene: 5818 Ensembl: ENSG00000110400 UCSC: uc001pwv.3 HGNC ID: 9706
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between PVRL1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
PVRL1	Jansen R, 2015	patients and normal controls	P-value=0.0000108;FDR=0.0363;beta=0.271	P-values, FDR and betas of 18 genes differentially expressed...... P-values, FDR and betas of 18 genes differentially expressed between control and current MDD groups (FDR<0.05) More...

Positive relationships between PVRL1 and other components at different levels (count: 0)

Positive relationship network of PVRL1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PVRL1 and MDD (count: 0)

Negative relationships between PVRL1 and other components at different levels (count: 0)

PVRL1 related SNPs in MK4MDD (count: 0)

PVRL1 related proteins in MK4MDD (count: 0)

PVRL1 related GO terms (count: 39)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0045216	cell-cell junction organization	biological process	TAS
GO:0005912	adherens junction	cellular component	NAS[12885915]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0016342	catenin complex	cellular component	IEA
GO:0005887	integral component of plasma membrane	cellular component	IBA
GO:0005576	extracellular region	cellular component	IEA
GO:0002934	desmosome organization	biological process	IEA
GO:0005102	receptor binding	molecular function	IBA
GO:0016337	single organismal cell-cell adhesion	biological process	NAS[12885915]
GO:0002089	lens morphogenesis in camera-type eye	biological process	IEA
GO:0070166	enamel mineralization	biological process	IEA
GO:0046790	virion binding	molecular function	IEA
GO:0007165	signal transduction	biological process	TAS[9616127]
GO:0046982	protein heterodimerization activity	molecular function	IEA
GO:0042803	protein homodimerization activity	molecular function	IBA; ISS
GO:0005886	plasma membrane	cellular component	TAS
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	biological process	IBA; ISS
GO:0046718	viral entry into host cell	biological process	NAS[12885915]
GO:0042734	presynaptic membrane	cellular component	IEA
GO:0015026	coreceptor activity	molecular function	TAS[9616127]
GO:0006955	immune response	biological process	NAS[10932188]
GO:0051963	regulation of synapse assembly	biological process	IEA
GO:0007411	axon guidance	biological process	IEA
GO:0043231	intracellular membrane-bounded organelle	cellular component	IEA
GO:0030246	carbohydrate binding	molecular function	IEA
GO:0005515	protein binding	molecular function	IPI[21982860]
GO:0060041	retina development in camera-type eye	biological process	IEA
GO:0016021	integral component of membrane	cellular component	NAS[10932188]
GO:0006826	iron ion transport	biological process	IEA
GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	biological process	IBA; ISS
GO:0001618	virus receptor activity	molecular function	IEA
GO:0030424	axon	cellular component	IEA
GO:0034329	cell junction assembly	biological process	TAS
GO:0008037	cell recognition	biological process	IBA
GO:0016020	membrane	cellular component	TAS[9616127]
GO:0050839	cell adhesion molecule binding	molecular function	IPI[12438620]
GO:0005913	cell-cell adherens junction	cellular component	IDA[10225955]
GO:0034332	adherens junction organization	biological process	TAS
GO:0032584	growth cone membrane	cellular component	IEA
GO:0007155	cell adhesion	biological process	NAS[12764381]

PVRL1 related KEGG pathways (count: 2)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04514	cell adhesion_molecules_cams	Cell adhesion molecules (CAMs)	Cell adhesion molecules are (glyco)proteins expressed on the...... Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cellcell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes. More...

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04520	adherens junction	Adherens junction	Cell-cell adherens junctions (AJs), the most common type of ...... Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion. More...

PVRL1 related BioCarta pathways (count: 0)

PVRL1 related Reactome pathways (count: 3)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19195	adherens junctions_interactions	The adherens junctions. The molecular constituents of adhere...... The adherens junctions. The molecular constituents of adherens junctions form adhesive units which are organized into higher order junctional adhesions that create a zipper-like seal between adjacent cells. Junctional adhesions function in epithelial cell polarization and in the coupling of cytoskeletons in adjacent cells that allow coordinated movements. During embryonic development, AJs function in specifying adhesion between cells and contribute in the sorting of different cell types. AJs also regulate cell polarity and shape, promote cell-cell communication and help mediate contact inhibition of cell growth. This module covers transdimerization events involving AJ transmembrane proteins. More...
REACT_19331	cell cell_adhesion_systems	Epithelial cell-cell contacts consist of three major adhesio...... Epithelial cell-cell contacts consist of three major adhesion systems: adherens junctions. TJs form physical barriers in various tissues and regulate paracellular transport of water, ions, and small water soluble molecules. Desmosomes mediate strong cell adhesion linking the intermediate filament cytoskeletons between cells and playing roles in wound repair, tissue morphogenesis, and cell signaling. Desmosomes will be covered in a later Reactome release. More...
REACT_20676	cell junction_organization

PVRL1 related interactors from protein-protein interaction data in HPRD (count: 7)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
PVRL1	PVR	No	in vitro	12011057
PVRL1	PARD3	No	in vitro;in vivo	12515806
PVRL1	MLLT4	No	in vitro;in vivo;yeast 2-hybrid	10225955 , 10617658
PVRL1	PVRL4	No	in vitro	12011057
PVRL1	PRNP	No	in vivo	15146195
PVRL1	PVRL1	Yes	in vitro	12011057
PVRL1	PVRL3	No	in vitro	12011057

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways

Gene mapped Reactome pathways