Gene Report

Basic Information

Approved Symbol	PSIP1
Approved Name	PC4 and SFRS1 interacting protein 1
Previous Symbol	PSIP2
Previous Name	PC4 and SFRS1 interacting protein 2
Symbol Alias	p52, LEDGF, p75
Location	9p22.2
Position	chr9:15464064-15511003 (-)
External Links	Entrez Gene: 11168 Ensembl: ENSG00000164985 UCSC: uc003zlw.4 HGNC ID: 9527
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between PSIP1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
PC4 and SFRS1 interacting protein 1	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between PSIP1 and other components at different levels (count: 0)

Positive relationship network of PSIP1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PSIP1 and MDD (count: 0)

Negative relationships between PSIP1 and other components at different levels (count: 0)

PSIP1 related SNPs in MK4MDD (count: 0)

PSIP1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
PC4 and SFRS1-interacting protein	O75475	0(0/0)	Gene mapped

PSIP1 related GO terms (count: 20)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0019048	virus-host interaction	biological process	IEA
GO:0097100	supercoiled DNA binding	molecular function	ISS
GO:0003682	chromatin binding	molecular function	IDA
GO:0005654	nucleoplasm	cellular component	IDA[9885563]; TAS
GO:0035327	transcriptionally active chromatin	cellular component	ISS
GO:0005720	nuclear heterochromatin	cellular component	IDA[12796494]
GO:0034399	nuclear periphery	cellular component	IDA[11512661]
GO:0033613	activating transcription factor binding	molecular function	IDA[9822615]
GO:0006351	transcription, DNA-dependent	biological process	IEA
GO:0005730	nucleolus	cellular component	IDA
GO:0006355	regulation of transcription, DNA-dependent	biological process	IEA
GO:0000395	mRNA 5'-splice site recognition	biological process	IDA[9885563]
GO:0016032	viral reproduction	biological process	TAS
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[9885563]
GO:0006979	response to oxidative stress	biological process	ISS
GO:0005829	cytosol	cellular component	TAS
GO:0005634	nucleus	cellular component	IDA
GO:0009408	response to heat	biological process	ISS
GO:0001105	RNA polymerase II transcription coactivator activity	molecular function	IDA[9885563]
GO:0005515	protein binding	molecular function	IPI[9885563]

PSIP1 related KEGG pathways (count: 0)

PSIP1 related BioCarta pathways (count: 0)

PSIP1 related Reactome pathways (count: 5)

ID	Name	Description
Gene mapped Reactome pathways
REACT_6266	early phase_of_hiv_life_cycle	In the early phase of HIV lifecycle, an active virion binds ...... In the early phase of HIV lifecycle, an active virion binds and enters a target cell mainly by specific interactions of the viral envelope proteins with host cell surface receptors. The virion core is uncoated to expose a viral nucleoprotein complex containing RNA and viral proteins. HIV RNA genome is reverse transcribed by the viral Reverse Transcriptase to form a cDNA copy, that gets inserted into host cell DNA. The viral Integrase enzyme is vital to carry out the integration of the viral cDNA into the host genome. The host DNA repair enzymes probably repair the breaks in DNA at the sites of integration. More...
REACT_7991	vpr mediated_nuclear_import_of_pics	Vpr appears to function in anchoring the PIC to the nuclear ...... Vpr appears to function in anchoring the PIC to the nuclear envelope. This anchoring likely involves interactions between Vpr and host nucleoporins. More...
REACT_6185	hiv infection	The global pandemic of Human Immunodeficiency Virus. HIV-1 a...... The global pandemic of Human Immunodeficiency Virus. HIV-1 and the less common HIV-2 belong to the family of retroviruses. HIV-1 contains a single-stranded RNA genome that is 9 kilobases in length and contains 9 genes that encode 15 different proteins. These proteins are classified as: structural proteins. HIV infection cycle can be divided into two phases: 1. An Early phase consisting of early events occuring after HIV infection of a susceptible target cell and a 2. Late phase comprising the later events in the HIV-infected cell resulting in the assembly of new infectious virions. The section titled HIV lifecycle consists of annotations of events in these two phases. The virus has developed various molecular strategies to suppress the antiviral immune responses. The section titled Host interactions of HIV factors will highlight these complex post-infection processes and the annotations will be released in near future. More...
REACT_6256	hiv life_cycle	The life cycle of HIV-1 is divided into early and late phase...... The life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surface. Most of the crucial concepts used to describe these processes were originally elucidated in studies of retroviruses associated with tumors in chickens, birds, and other animal model systems, and the rapid elucidation of the basic features of the HIV-1 life cycle was critically dependent on the intellectual framework provided by these earlier studies. This earlier work has been very well summarized ; here for brevity and clarity we focus on experimental studies specific to the HIV-1 life cycle. More...
REACT_6288	host interactions_of_hiv_factors	Like all viruses, HIV-1 must co-opt the host cell macromolec...... Like all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewise requires evasion of APOBEC3G-mediated mutagenesis of reverse transcripts, a process mediated by the viral Vif protein. More...

PSIP1 related interactors from protein-protein interaction data in HPRD (count: 4)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
PSIP1	HCFC1	No	in vitro	9822615
PSIP1	CASP7	No	in vitro	12181742
PSIP1	SFRS1	No	in vitro;in vivo	9885563
PSIP1	CASP3	No	in vitro	12181742

Gene Report

Gene mapped GO terms

Gene mapped Reactome pathways