MK4MDD

Pathway Report

Basic Information
Name PKC-catalysed phosphorylation of inhibitory phosphoprotein of myosin phosphatase
BioCarta Link ID: MYOSIN_PATHWAY
Name: myosin pathway
Brief Description: PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase
Full Description: The phosphorylation of myosin affects its role in smooth muscle contraction, platelet formation and possibly other processes. Phosphorylation by myosin light chain kinase (MLCK) increases myosin activity and dephosphorylation by myosin phosphatase decreases myosin activity. CPI, a factor that binds to and inhibits myosin phosphatase, is a target of phosphorylation by PKC and PKN. The inhibitory activity of CPI is regulated by its own phosphorylation state; when CPI is phosphorylated, its inhibitory activity is increased. The activation of signal transduction cascades such as GPCR pathways can lead to activation of PKC, phosphorylation of CPI, inhibition of myosin phosphatase, increased myosin phosphorylation and increased smooth muscle contraction or platelet release. The action of histamine in vasoconstriction, for example, may be mediated by activation of PKC through the histamine receptor, resulting in phosphorylation of CPI-17, increased inhibition of myosin phosphatase, and increased smooth muscle contraction.
No. of Studies (Positive/Negative) 1 (1/0) Help

Positive relationship between PKC-catalysed phosphorylation of inhibitory phosphoprotein of myosin phosphatase and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
PKC-catalysed phosphorylation of inhibitory phosphoprotein of myosin phosphatase Kao CF, 2012 patients and normal controls We found 17 significantly enriched pathways for depression We found 17 significantly enriched pathways for depression

Positive relationships between PKC-catalysed phosphorylation of inhibitory phosphoprotein of myosin phosphatase and other components at different levels (count: 0) Help
Positive relationship network of PKC-catalysed phosphorylation of inhibitory phosphoprotein of myosin phosphatase in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
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Negative relationships between PKC-catalysed phosphorylation of inhibitory phosphoprotein of myosin phosphatase and MDD (count: 0)
Negative relationships between PKC-catalysed phosphorylation of inhibitory phosphoprotein of myosin phosphatase and other components at different levels (count: 0) Help
Pathway PKC-catalysed phosphorylation of inhibitory phosphoprotein of myosin phosphatase related genes in MK4MDD (count: 4)