Gene Report

Basic Information

Approved Symbol	PIGF
Approved Name	phosphatidylinositol glycan anchor biosynthesis, class F
Previous Name	phosphatidylinositol glycan, class F
Location	2p21-p16
Position	chr2:46808413-46844251 (-)
External Links	Entrez Gene: 5281 Ensembl: ENSG00000151665 UCSC: uc002rvd.3 HGNC ID: 8962
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between PIGF and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
PIGF	Chu TT, 2009	Patients and nomal controls		Down regulation, fold change([MD] vs [C]) 2.4792037 Down regulation, fold change([MD] vs [C]) 2.4792037

Positive relationships between PIGF and other components at different levels (count: 0)

Positive relationship network of PIGF in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PIGF and MDD (count: 0)

Negative relationships between PIGF and other components at different levels (count: 0)

PIGF related SNPs in MK4MDD (count: 0)

PIGF related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Phosphatidylinositol-glycan biosynthesis class F protein	Q07326	0(0/0)	Gene mapped

PIGF related GO terms (count: 8)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006506	GPI anchor biosynthetic process	biological process	ISS
GO:0005789	endoplasmic reticulum membrane	cellular component	ISS; TAS
GO:0004307	ethanolaminephosphotransferase activity	molecular function	TAS[8463218]
GO:0016021	integral to membrane	cellular component	IEA
GO:0006501	C-terminal protein lipidation	biological process	TAS
GO:0043687	post-translational protein modification	biological process	TAS
GO:0016254	preassembly of GPI anchor in ER membrane	biological process	TAS
GO:0044267	cellular protein metabolic process	biological process	TAS

PIGF related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa00563	glycosylphosphatidylinositol gpi_anchor_biosynthesis	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis	Cell surface proteins can be attached to the cell membrane v...... Cell surface proteins can be attached to the cell membrane via the glycolipid structure called glycosylphosphatidylinositol (GPI) anchor. Hundreds of GPI-anchored proteins have been identified in many eukaryotes ranging from protozoa and fungi to mammals. All protein-linked GPI anchors share a common core structure, characterized by the substructure Man (a14) GlcN (a1-6) myo-inositol-1P-lipid. Biosynthesis of GPI anchors proceeds in three stages: (i) preassembly of a GPI precursor in the ER membrane, (ii) attachment of the GPI to the C-terminus of a newly synthesized protein in the lumen of the ER, and (iii) lipid remodeling and/or carbohydrate side-chain modifications in the ER and the Golgi. Defects of GPI anchor biosynthesis gene result in a genetic disorder, paroxysmal nocturnal hemoglobinuria. More...

PIGF related BioCarta pathways (count: 0)

PIGF related Reactome pathways (count: 4)

ID	Name	Description
Gene mapped Reactome pathways
REACT_952	synthesis of_glycosylphosphatidylinositol	Glycosylphosphatidyl inositol. These variant GPI molecules m...... Glycosylphosphatidyl inositol. These variant GPI molecules may be used for tissue-specific protein modifications, or may function independently. The steps of GPI synthesis were first identified by isolating large numbers of mutant cell lines that had lost the ability to express GPI anchored proteins on their surfaces. Somatic cell hybrid analyses of these lines allowed the definition of complementation groups corresponding to distinct mutated genes, and cDNAs corresponding to normal forms of these genes were identified on the basis of their abilities to restore normal cell surface protein expression in mutant cells. Co-precipitation experiments with tagged cloned proteins have allowed the identification of additional proteins involved in GPI anchor biosynthesis. More...
REACT_17015	metabolism of_proteins	Protein metabolism comprises the pathways of translation, po...... Protein metabolism comprises the pathways of translation, post-translational modification and protein folding. More...
REACT_1069	post translational_protein_modification	After translation, many newly formed proteins undergo furthe...... After translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the body. These modifications include the internal peptide bond cleavages that activate proenzymes, the attachment of oligosaccharide moieties to membrane-bound and secreted proteins, the attachment of lipid or glycolipid moieties that serve to anchor proteins to cellular membranes, and the vitamin K-dependent attachment of carboxyl groups to glutamate residues. More...
REACT_1853	synthesis of_gpi_anchored_proteins	Glycosylphosphatidyl inositol (GPI) acts as a membrane ancho...... Glycosylphosphatidyl inositol (GPI) acts as a membrane anchor for many cell surface proteins. GPI is synthesized in the endoplasmic reticulum. In humans, a single pathway consisting of eleven reactions appears to be responsible for the synthesis of the major GPI species involved in membrane protein anchoring. As a nascent protein fated to become GPI-anchored moves into the lumen of the endoplasmic reticulum, it is attacked by a transamidase complex that cleaves it near its carboxy terminus and attaches an acylated GPI moiety. The GPI moiety is deacylated, yielding a protein-GPI conjugate that can be efficiently transported to the Golgi apparatus. More...

PIGF related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
PIGF	PIGO	No	in vivo	10781593
PIGF	PIGG	No	in vitro;in vivo	15632136

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways