Gene Report

Basic Information

Approved Symbol	PIEZO2
Approved Name	piezo-type mechanosensitive ion channel component 2
Previous Symbol	FAM38B2, C18orf30, C18orf58, FAM38B
Previous Name	chromosome 18 open reading frame 30, "chromosome 18 open reading frame 58", "family with sequence similarity 38, member B"
Symbol Alias	FLJ23403, FLJ23144, HsT748, HsT771, FLJ34907
Location	18p11.21
Position	chr18:10670244-11148761 (-)
External Links	Entrez Gene: 63895 Ensembl: ENSG00000154864 UCSC: uc002kos.2 HGNC ID: 26270
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between PIEZO2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
FAM38B	Guilloux JP, 2012	patients and normal controls		genes significantly affected in female MDD subjects genes significantly affected in female MDD subjects

Positive relationships between PIEZO2 and other components at different levels (count: 0)

Positive relationship network of PIEZO2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PIEZO2 and MDD (count: 0)

Negative relationships between PIEZO2 and other components at different levels (count: 0)

PIEZO2 related SNPs in MK4MDD (count: 0)

PIEZO2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Piezo-type mechanosensitive ion channel component 2	Q9H5I5	0(0/0)	Gene mapped

PIEZO2 related GO terms (count: 5)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005261	cation channel activity	molecular function	IEA
GO:0016021	integral to membrane	cellular component	IEA
GO:0006812	cation transport	biological process	ISS
GO:0008381	mechanically-gated ion channel activity	molecular function	IEA
GO:0042391	regulation of membrane potential	biological process	IEA

PIEZO2 related KEGG pathways (count: 0)

PIEZO2 related BioCarta pathways (count: 0)

PIEZO2 related Reactome pathways (count: 0)

PIEZO2 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms