MK4MDD

Pathway Report

Basic Information
Name Neurotrophin signaling pathway
GO Link ID: GO:0038179
Name: neurotrophin signaling pathway
Type: biological process
Description "A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons. "
No. of Studies (Positive/Negative) 1 (1/0) Help

Positive relationship between Neurotrophin signaling pathway and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
Neurotrophin signaling pathway Network and C, 2015 patients only FDR q-value=0.0793576 The degree of rank correlation between pathways across pairs...... The degree of rank correlation between pathways across pairs of disorders was significant (Supplementary Tables 4 and 6), with 49 pathways with combined q-value <0.1 spanning the three adult disorders (Table 2, Supplementary Table 7). Of these, 16 are significant at q < 0.05, with the top pathway (GO:51568: histone H3-K4 methylation) having a q = 0.0003 (Table 2). These results are more significant than those observed in any of the disorders analyzed alone. We then use multidimensional scaling (MDS) to cluster these sets in terms of shared genes. More...

Positive relationships between Neurotrophin signaling pathway and other components at different levels (count: 0) Help
Positive relationship network of Neurotrophin signaling pathway in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Neurotrophin signaling pathway and MDD (count: 0)
Negative relationships between Neurotrophin signaling pathway and other components at different levels (count: 0) Help
Pathway Neurotrophin signaling pathway related genes in MK4MDD (count: 1)