MK4MDD

Gene Report

Basic Information
Approved Symbol MARCKS
Approved Name myristoylated alanine-rich protein kinase C substrate
Previous Symbol MACS
Previous Name "myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L)"
Symbol Alias PKCSL, 80K-L
Location 6q21
Position chr6:114181756-114184652 (+)
External Links Entrez Gene: 4082
Ensembl: ENSG00000155130
UCSC: uc003pvy.4
HGNC ID: 6759
No. of Studies (Positive/Negative) 1(1/0) Help
Type Literature-origin

Positive relationships between MARCKS and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
MARCKS Redei, 2015 Patients and nomal controls P-value=0.005 Blood transcript levels of nine markers¡ªADCY3(adenylate cyc...... Blood transcript levels of nine markers¡ªADCY3(adenylate cyclase 3, which shows suggestive associationin GWASs with MDD,52 but highly significant association with body mass index in children53), DGKA, FAM46A, IGSF4A/CADM1,KIAA1539, MARCKS (myristoylated alanine-rich protein kinase C substrate, regulated by Ca2+/calmodulin), PSME1, RAPH1, and TLR7 differed significantly between MDD patients and ND controls at baseline. More...

Positive relationships between MARCKS and other components at different levels (count: 0) Help
Positive relationship network of MARCKS in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between MARCKS and MDD (count: 0)
Negative relationships between MARCKS and other components at different levels (count: 0) Help
MARCKS related SNPs in MK4MDD (count: 0)
MARCKS related proteins in MK4MDD (count: 0)
MARCKS related GO terms (count: 33)
MARCKS related KEGG pathways (count: 1)
MARCKS related BioCarta pathways (count: 1)
MARCKS related Reactome pathways (count: 3)
MARCKS related interactors from protein-protein interaction data in HPRD (count: 7)