MK4MDD

Brain Morphology and Function Report

Basic Information
Name Limbic system
Brain Morphology "The limbic system (or Paleomammalian brain) is a set of brain structures including the hippocampus, amygdala, anterior thalamic nuclei, septum, limbic cortex and fornix, which seemingly support a variety of functions including emotion, behavior, long term memory, and olfaction. The limbic system is the set of brain structures that forms the inner border of the cortex. The cortical components generally have fewer layers than the classical 6-layered neocortex, and are usually classified as allocortex or archicortex."
Brain Function "The limbic system operates by influencing the endocrine system and the autonomic nervous system. It is highly interconnected with the nucleus accumbens, the brain's pleasure center, which plays a role in sexual arousal and the ""high"" derived from certain recreational drugs. These responses are heavily modulated by dopaminergic projections from the limbic system. In 1954, Olds and Milner found that rats with metal electrodes implanted into their nucleus accumbens as well as their septal nuclei repeatedly pressed a lever activating this region, and did so in preference to eating and drinking, eventually dying of exhaustion. The limbic system is also tightly connected to the prefrontal cortex. Some scientists contend that this connection is related to the pleasure obtained from solving problems. To cure severe emotional disorders, this connection was sometimes surgically severed, a procedure of psychosurgery, called a prefrontal lobotomy (this is actually a misnomer). Patients who underwent this procedure often became passive and lacked all motivation."
No. of Studies (Positive/Negative) 3(3/0) Help

Positive relationships between Limbic system and MDD (count: 3)
Name in Literature Reference Research Type Statistical Result Relation Description Help
limbic-subcortical regions Fu, 2007 patients and normal controls An attenuated dynamic range of response in limbic-subcortica...... An attenuated dynamic range of response in limbic-subcortical regions was evident in the depressed patients, relative to the comparison subjects. More...
limbic system Zou, 2010 patients and normal controls Depressed patients showed significant gray matter volume red...... Depressed patients showed significant gray matter volume reduction in the bilateral limbic system, especially in hippocampus. More...
limbic system Korgaonkar, 2010 patients and normal controls average reduction of 7.8% Compared with controls, melancholic participants showed an a...... Compared with controls, melancholic participants showed an average reduction of 7.8% in fractional anisotropy over WM regions associated with the limbic system, dorsolateral prefrontal cortex, thalamic projection fibers, corpus callosum, and other association fibers. More...

Positive relationships between Limbic system and other components at different levels (count: 0) Help
Positive relationship network of Limbic system in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Limbic system and MDD (count: 0)
Negative relationships between Limbic system and other components at different levels (count: 0) Help
Limbic system involved components (count: 16)
Name Type  
Hippocampus brain morphology and function
Amygdala brain morphology and function
Limbic system brain morphology and function
Septal area brain morphology and function
Limbic lobe brain morphology and function
Limbic system brain morphology and function
Limbic system brain morphology and function
Septal area brain morphology and function
Parahippocampal gyrus brain morphology and function
Cingulate gyrus brain morphology and function
Dentate gyrus brain morphology and function
Entorhinal cortex brain morphology and function
Limbic system brain morphology and function
Limbic system brain morphology and function
Nucleus accumbens brain morphology and function
Orbitofrontal cortex brain morphology and function