"The limbic system (or Paleomammalian brain) is a set of brain structures including the hippocampus, amygdala, anterior thalamic nuclei, septum, limbic cortex and fornix, which seemingly support a variety of functions including emotion, behavior, long term memory, and olfaction. The limbic system is the set of brain structures that forms the inner border of the cortex. The cortical components generally have fewer layers than the classical 6-layered neocortex, and are usually classified as allocortex or archicortex."
"The limbic system operates by influencing the endocrine system and the autonomic nervous system. It is highly interconnected with the nucleus accumbens, the brain's pleasure center, which plays a role in sexual arousal and the ""high"" derived from certain recreational drugs. These responses are heavily modulated by dopaminergic projections from the limbic system. In 1954, Olds and Milner found that rats with metal electrodes implanted into their nucleus accumbens as well as their septal nuclei repeatedly pressed a lever activating this region, and did so in preference to eating and drinking, eventually dying of exhaustion. The limbic system is also tightly connected to the prefrontal cortex. Some scientists contend that this connection is related to the pleasure obtained from solving problems. To cure severe emotional disorders, this connection was sometimes surgically severed, a procedure of psychosurgery, called a prefrontal lobotomy (this is actually a misnomer). Patients who underwent this procedure often became passive and lacked all motivation."
No. of Studies (Positive/Negative)
Positive relationships between Limbic system and MDD (count: 3)
An attenuated dynamic range of response in limbic-subcortica......
An attenuated dynamic range of response in limbic-subcortical regions was evident in the depressed patients, relative to the comparison subjects.More...
Compared with controls, melancholic participants showed an a......
Compared with controls, melancholic participants showed an average reduction of 7.8% in fractional anisotropy over WM regions associated with the limbic system, dorsolateral prefrontal cortex, thalamic projection fibers, corpus callosum, and other association fibers.More...
Positive relationships between Limbic system and other components at different levels (count: 0)
Positive relationship network of Limbic system in MK4MDD
Network loading ...
1. The different color of the nodes denotes the level of the nodes.
Protein and Other Molecule
Cell and Molecular Pathway
Cognition and Behavior
Symptoms and Signs
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node.
Right-click will show also the menus to link to the report page of the node and remove the node and related edges.
Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web
Negative relationships between Limbic system and MDD (count: 0)
Negative relationships between Limbic system and other components at different levels (count: 0)
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
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Last update: October 10, 2015