Gene Report

Basic Information

Approved Symbol	LMO3
Approved Name	LIM domain only 3 (rhombotin-like 2)
Previous Symbol	RBTNL2
Symbol Alias	Rhom-3, DAT1
Location	12p13
Position	chr12:16701306-16761148 (-)
External Links	Entrez Gene: 55885 Ensembl: ENSG00000048540 UCSC: uc010shy.2 HGNC ID: 6643
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between LMO3 and MDD (count: 0)

Positive relationships between LMO3 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
Lmo3		Histone-lysine N-methyltransferase SETDB1(Setdb1 (Set domain, bifurcated 1))	protein	Jiang Y, 2010	animal model		Gene was occupied by Setdb1 in neuron Gene was occupied by Setdb1 in neuron

Positive relationship network of LMO3 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between LMO3 and MDD (count: 0)

Negative relationships between LMO3 and other components at different levels (count: 0)

LMO3 related SNPs in MK4MDD (count: 0)

LMO3 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
LIM domain only protein 3	Q8TAP4	0(0/0)	Gene mapped

LMO3 related GO terms (count: 3)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006351	transcription, DNA-dependent	biological process	IEA
GO:0008270	zinc ion binding	molecular function	IEA
GO:0006355	regulation of transcription, DNA-dependent	biological process	IEA

LMO3 related KEGG pathways (count: 0)

LMO3 related BioCarta pathways (count: 0)

LMO3 related Reactome pathways (count: 0)

LMO3 related interactors from protein-protein interaction data in HPRD (count: 17)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
LMO3	RORA	No	yeast 2-hybrid	16713569
LMO3	ALS2CR8	No	yeast 2-hybrid	16189514
LMO3	ZBTB43	Yes	yeast 2-hybrid	16189514
LMO3	MBIP	No	yeast 2-hybrid	16189514
LMO3	GABPB1	No	yeast 2-hybrid	16189514
LMO3	RFX6	No	yeast 2-hybrid	16189514
LMO3	MDFI	No	yeast 2-hybrid	16189514
LMO3	NHLH2	No	in vivo	15930276
LMO3	HNRNPM	No	yeast 2-hybrid	16189514
LMO3	HNRNPC	No	yeast 2-hybrid	16189514
LMO3	RALYL	No	yeast 2-hybrid	16189514
LMO3	AIMP2	No	yeast 2-hybrid	16189514
LMO3	C19orf50	No	yeast 2-hybrid	16189514
LMO3	PHC2	No	yeast 2-hybrid	16189514
LMO3	CCDC85B	No	yeast 2-hybrid	16189514
LMO3	LDB1	No	yeast 2-hybrid	16189514
LMO3	$ZBTB8$	No	yeast 2-hybrid	16189514

Gene Report

Gene mapped GO terms