Gene Report

Basic Information

Approved Symbol	LHPP
Approved Name	phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Symbol Alias	HDHD2B
Location	10q26.2
Position	chr10:126150341-126302710 (+)
External Links	Entrez Gene: 64077 Ensembl: ENSG00000107902 UCSC: uc001lhs.2 HGNC ID: 30042
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between LHPP and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
LHPP	Neff, 2009	patients and normal controls		Sequencing of all known genes in the linkage region revealed...... Sequencing of all known genes in the linkage region revealed disease-segregating single-nucleotide polymorphisms (SNPs) in LHPP. LHPP SNPs were also associated with major depression in both Utah and Ashkenazi populations. More...

Positive relationships between LHPP and other components at different levels (count: 0)

Positive relationship network of LHPP in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between LHPP and MDD (count: 0)

Negative relationships between LHPP and other components at different levels (count: 0)

LHPP related SNPs in MK4MDD (count: 0)

LHPP related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase	Q9H008	0(0/0)	Gene mapped

LHPP related GO terms (count: 10)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005730	nucleolus	cellular component	IDA
GO:0004427	inorganic diphosphatase activity	molecular function	IDA[12801912]
GO:0006470	protein dephosphorylation	biological process	ISS
GO:0042803	protein homodimerization activity	molecular function	IPI[12801912]
GO:0000287	magnesium ion binding	molecular function	ISS
GO:0006796	phosphate-containing compound metabolic process	biological process	IDA[12801912]
GO:0005634	nucleus	cellular component	IDA
GO:0005737	cytoplasm	cellular component	IDA
GO:0008969	phosphohistidine phosphatase activity	molecular function	ISS
GO:0005829	cytosol	cellular component	IDA[16430861]

LHPP related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa00190	oxidative phosphorylation	Oxidative phosphorylation

LHPP related BioCarta pathways (count: 0)

LHPP related Reactome pathways (count: 0)

LHPP related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways