Gene Report

Basic Information

Approved Symbol	KRT17
Approved Name	keratin 17
Previous Symbol	PCHC1
Location	17q21.2
Position	chr17:39775692-39780882 (-)
External Links	Entrez Gene: 3872 Ensembl: ENSG00000128422 UCSC: uc002hxh.2 HGNC ID: 6427
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between KRT17 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Keratin 17	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between KRT17 and other components at different levels (count: 0)

Positive relationship network of KRT17 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between KRT17 and MDD (count: 0)

Negative relationships between KRT17 and other components at different levels (count: 0)

KRT17 related SNPs in MK4MDD (count: 0)

KRT17 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Keratin, type I cytoskeletal 17	Q04695	0(0/0)	Gene mapped

KRT17 related GO terms (count: 15)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005515	protein binding	molecular function	IPI[16189514]
GO:0005200	structural constituent of cytoskeleton	molecular function	TAS[1281771]
GO:0002009	morphogenesis of an epithelium	biological process	IEA
GO:0031424	keratinization	biological process	IEA
GO:0032395	MHC class II receptor activity	molecular function	IDA[15795121]
GO:0071944	cell periphery	cellular component	IEA
GO:0007165	signal transduction	biological process	IMP[15795121]
GO:0051798	positive regulation of hair follicle development	biological process	IEA
GO:0042289	MHC class II protein binding	molecular function	IPI[15795121]
GO:0005737	cytoplasm	cellular component	IEA
GO:0045109	intermediate filament organization	biological process	IEA
GO:0008544	epidermis development	biological process	TAS[7539673]
GO:0005882	intermediate filament	cellular component	IEA
GO:0030307	positive regulation of cell growth	biological process	IEA
GO:0045727	positive regulation of translation	biological process	IEA

KRT17 related KEGG pathways (count: 0)

KRT17 related BioCarta pathways (count: 0)

KRT17 related Reactome pathways (count: 0)

KRT17 related interactors from protein-protein interaction data in HPRD (count: 4)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
KRT17	KRT6A	No	yeast 2-hybrid	16189514
KRT17	KRT7	No	in vivo	11591653
KRT17	CCDC85B	No	yeast 2-hybrid	16189514
KRT17	EGFR	No	in vitro;in vivo	12577067

Gene Report

Gene mapped GO terms