Gene Report

Basic Information

Approved Symbol	IRAK2
Approved Name	interleukin-1 receptor-associated kinase 2
Location	3p25.2
Position	chr3:10283913-10285427 (+)
External Links	Entrez Gene: 3656 Ensembl: ENSG00000134070 UCSC: uc003bve.1 HGNC ID: 6113
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between IRAK2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
IRAK2	Carvalho LA, 2014	patients and normal controls	FC=3; P-value=0.006	Thirty-four of the 47 monocyte inflammatory-related genes w...... Thirty-four of the 47 monocyte inflammatory-related genes were significantly upregulated and 2 were significantly downregulated as compared to controls More...

Positive relationships between IRAK2 and other components at different levels (count: 0)

Positive relationship network of IRAK2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between IRAK2 and MDD (count: 0)

Negative relationships between IRAK2 and other components at different levels (count: 0)

IRAK2 related SNPs in MK4MDD (count: 0)

IRAK2 related proteins in MK4MDD (count: 0)

IRAK2 related GO terms (count: 38)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0006954	inflammatory response	biological process	TAS[9374458]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005634	nucleus	cellular component	IBA
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway	biological process	TAS
GO:0005524	ATP binding	molecular function	IEA
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	biological process	TAS
GO:0034146	toll-like receptor 5 signaling pathway	biological process	TAS
GO:0046982	protein heterodimerization activity	molecular function	IPI[10383454]
GO:0045087	innate immune response	biological process	TAS
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0034162	toll-like receptor 9 signaling pathway	biological process	TAS
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway	biological process	TAS
GO:0034142	toll-like receptor 4 signaling pathway	biological process	TAS
GO:0070498	interleukin-1-mediated signaling pathway	biological process	IMP[10383454]
GO:0034166	toll-like receptor 10 signaling pathway	biological process	TAS
GO:0006468	protein phosphorylation	biological process	TAS[9374458]
GO:0032088	negative regulation of NF-kappaB transcription factor activity	biological process	IMP[10383454]
GO:0010008	endosome membrane	cellular component	TAS
GO:0001959	regulation of cytokine-mediated signaling pathway	biological process	IMP[10383454]
GO:0005829	cytosol	cellular component	TAS
GO:0002224	toll-like receptor signaling pathway	biological process	TAS
GO:0007254	JNK cascade	biological process	TAS
GO:0034134	toll-like receptor 2 signaling pathway	biological process	TAS
GO:0034138	toll-like receptor 3 signaling pathway	biological process	TAS
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	biological process	TAS
GO:0005515	protein binding	molecular function	IPI[11544529\|18636090\|21903422]
GO:0002756	MyD88-independent toll-like receptor signaling pathway	biological process	TAS
GO:0070555	response to interleukin-1	biological process	IMP[10383454]
GO:0031663	lipopolysaccharide-mediated signaling pathway	biological process	IEA
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	biological process	TAS[10383454]
GO:0005737	cytoplasm	cellular component	IBA
GO:0005886	plasma membrane	cellular component	TAS
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	biological process	TAS
GO:0007249	I-kappaB kinase/NF-kappaB signaling	biological process	TAS[9374458]
GO:0051403	stress-activated MAPK cascade	biological process	TAS
GO:0042803	protein homodimerization activity	molecular function	IPI[10383454]
GO:0051092	positive regulation of NF-kappaB transcription factor activity	biological process	IMP[10383454]; TAS
GO:0004674	protein serine/threonine kinase activity	molecular function	IBA
GO:0000187	activation of MAPK activity	biological process	TAS

IRAK2 related KEGG pathways (count: 2)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04722	neurotrophin signaling_pathway	Neurotrophin signaling pathway	Neurotrophins are a family of trophic factors involved in di...... Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and nagative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory. More...
hsa04210	apoptosis	Apoptosis	Apoptosis is a genetically controlled mechanisms of cell dea...... Apoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily members and ligands) and the intrinsic (mitochondria-associated) pathways, both of which are found in the cytoplasm. The extrinsic pathway is triggered by death receptor engagement, which initiates a signaling cascade mediated by caspase-8 activation. Caspase-8 both feeds directly into caspase-3 activation and stimulates the release of cytochrome c by the mitochondria. Caspase-3 activation leads to the degradation of cellular proteins necessary to maintain cell survival and integrity. The intrinsic pathway occurs when various apoptotic stimuli trigger the release of cytochrome c from the mitochondria (independently of caspase-8 activation). Cytochrome c interacts with Apaf-1 and caspase-9 to promote the activation of caspase-3. Recent studies point to the ER as a third subcellular compartment implicated in apoptotic execution. Alterations in Ca2+ homeostasis and accumulation of misfolded proteins in the ER cause ER stress. Prolonged ER stress can result in the activation of BAD and/or caspase-12, and execute apoptosis. More...

IRAK2 related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
IL1R_PATHWAY	il1r pathway	Signal transduction through IL1R	Interleukin-1 (IL-1) is a pro-inflammatory cytokine that sig...... Interleukin-1 (IL-1) is a pro-inflammatory cytokine that signals primarily through the type 1 IL-1 receptor (IL-1R1). The activities of IL-1 include induction of fever, expression of vascular adhesion molecules, and roles in arthritis and septic shock. The inflammatory activities of IL-1 are partially derived by transcriptionally inducing expression of cytokines such as TNF-alpha and interferons, as well as inducing the expression of other inflammation-related genes. There are two forms of IL-1 encoded by distinct genes, IL-1 alpha and IL-1 beta. IL-1 beta is produced as a 269 amino acid precursor that is cleaved by IL-1beta converting enzyme (ICE) to the active IL-1 beta form that is secreted. IL-1 signaling is opposed by the naturally occurring peptide IL-1 receptor antagonist which is a therapeutic agent for the treatment of arthritis. The type 1 IL-1 receptor protein binds IL-1 beta but requires the IL-1 receptor accessory protein (IL-1RAcP) to transduce a signal. IL-1 binding causes activation of two kinases, IRAK-1 and IRAK-2, associated with the IL-1 receptor complex. IRAK-1 (IL-1 Receptor Associated Kinase) activates and recruits TRAF6 to the IL-1 receptor complex. TRAF6 activates two pathways, one leading to NF-kB activation and another leading to c-jun activation. The TRAF associated protein ECSIT leads to c-Jun activation through the Map kinase/JNK signaling system. TRAF6 also signals through the TAB1/TAK1 kinases to trigger the degradation of I-kB, and activation of NF-kB. The IL-1 signaling cascade represents a highly conserved response to pathogens through evolution, with homologs in insects and even in plants. The signal transduction cascade utilized by IL-1 receptor is similar to that of TNF, resulting in NF-kB activation, and is most similar to that of the Toll-like receptors that also participate in inflammatory signaling responses to pathogen components like endotoxin. More...

IRAK2 related Reactome pathways (count: 0)

IRAK2 related interactors from protein-protein interaction data in HPRD (count: 15)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
IRAK2	IRAK1	No	in vivo	10383454
IRAK2	IRAK3	No	in vivo	10383454
IRAK2	PELI3	No	in vitro	17675297
IRAK2	TIRAP	No	in vivo	11544529
IRAK2	PELI1	No	in vitro	17675297
IRAK2	SMAD2	No	in vivo	15761153
IRAK2	IL1R1	No	in vitro;in vivo	9374458 , 12659850
IRAK2	IRAK2	Yes	in vivo	10383454
IRAK2	TRAF6	No	in vivo	9374458
IRAK2	HRAS	No	in vivo	11744690
IRAK2	MYD88	No	in vitro;in vivo	9374458 , 12659850
IRAK2	SMURF1	No	in vivo	15761153
IRAK2	TICAM2	No	in vitro;in vivo	12721283
IRAK2	TLR4	No	in vivo	9625770
IRAK2	PELI2	No	in vitro	17675297

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped BioCarta pathways