
Gene Report
Approved Symbol | IRAK2 |
---|---|
Approved Name | interleukin-1 receptor-associated kinase 2 |
Location | 3p25.2 |
Position | chr3:10283913-10285427 (+) |
External Links |
Entrez Gene: 3656 Ensembl: ENSG00000134070 UCSC: uc003bve.1 HGNC ID: 6113 |
No. of Studies (Positive/Negative) | 1(1/0)
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Type | Literature-origin |
Name in Literature | Reference | Research Type | Statistical Result | Relation Description | ![]() |
---|---|---|---|---|---|
IRAK2 | Carvalho LA, 2014 | patients and normal controls | FC=3; P-value=0.006 | Thirty-four of the 47 monocyte inflammatory-related genes w...... Thirty-four of the 47 monocyte inflammatory-related genes were significantly upregulated and 2 were significantly downregulated as compared to controls More... |
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus | Protein and Other Molecule | Cell and Molecular Pathway | Neural System | Cognition and Behavior | Symptoms and Signs | Environment | MDD |
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2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Literature-origin GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0006954 | inflammatory response | biological process | TAS[9374458] |
Gene mapped GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0005634 | nucleus | cellular component | IBA | |
GO:0038123 | toll-like receptor TLR1:TLR2 signaling pathway | biological process | TAS | |
GO:0005524 | ATP binding | molecular function | IEA | |
GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway | biological process | TAS | |
GO:0034146 | toll-like receptor 5 signaling pathway | biological process | TAS | |
GO:0046982 | protein heterodimerization activity | molecular function | IPI[10383454] | |
GO:0045087 | innate immune response | biological process | TAS | |
GO:0032553 | ribonucleotide binding | molecular function | IEA | |
GO:0034162 | toll-like receptor 9 signaling pathway | biological process | TAS | |
GO:0038124 | toll-like receptor TLR6:TLR2 signaling pathway | biological process | TAS | |
GO:0034142 | toll-like receptor 4 signaling pathway | biological process | TAS | |
GO:0070498 | interleukin-1-mediated signaling pathway | biological process | IMP[10383454] | |
GO:0034166 | toll-like receptor 10 signaling pathway | biological process | TAS | |
GO:0006468 | protein phosphorylation | biological process | TAS[9374458] | |
GO:0032088 | negative regulation of NF-kappaB transcription factor activity | biological process | IMP[10383454] | |
GO:0010008 | endosome membrane | cellular component | TAS | |
GO:0001959 | regulation of cytokine-mediated signaling pathway | biological process | IMP[10383454] | |
GO:0005829 | cytosol | cellular component | TAS | |
GO:0002224 | toll-like receptor signaling pathway | biological process | TAS | |
GO:0007254 | JNK cascade | biological process | TAS | |
GO:0034134 | toll-like receptor 2 signaling pathway | biological process | TAS | |
GO:0034138 | toll-like receptor 3 signaling pathway | biological process | TAS | |
GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | biological process | TAS | |
GO:0005515 | protein binding | molecular function | IPI[11544529|18636090|21903422] | |
GO:0002756 | MyD88-independent toll-like receptor signaling pathway | biological process | TAS | |
GO:0070555 | response to interleukin-1 | biological process | IMP[10383454] | |
GO:0031663 | lipopolysaccharide-mediated signaling pathway | biological process | IEA | |
GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | biological process | TAS[10383454] | |
GO:0005737 | cytoplasm | cellular component | IBA | |
GO:0005886 | plasma membrane | cellular component | TAS | |
GO:0035872 | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | biological process | TAS | |
GO:0007249 | I-kappaB kinase/NF-kappaB signaling | biological process | TAS[9374458] | |
GO:0051403 | stress-activated MAPK cascade | biological process | TAS | |
GO:0042803 | protein homodimerization activity | molecular function | IPI[10383454] | |
GO:0051092 | positive regulation of NF-kappaB transcription factor activity | biological process | IMP[10383454]; TAS | |
GO:0004674 | protein serine/threonine kinase activity | molecular function | IBA | |
GO:0000187 | activation of MAPK activity | biological process | TAS |
Gene mapped KEGG pathways | ||||
ID | Name | Brief Description | Full Description | |
---|---|---|---|---|
hsa04722 | neurotrophin signaling_pathway | Neurotrophin signaling pathway | Neurotrophins are a family of trophic factors involved in di...... Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and nagative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory. More... | |
hsa04210 | apoptosis | Apoptosis | Apoptosis is a genetically controlled mechanisms of cell dea...... Apoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily members and ligands) and the intrinsic (mitochondria-associated) pathways, both of which are found in the cytoplasm. The extrinsic pathway is triggered by death receptor engagement, which initiates a signaling cascade mediated by caspase-8 activation. Caspase-8 both feeds directly into caspase-3 activation and stimulates the release of cytochrome c by the mitochondria. Caspase-3 activation leads to the degradation of cellular proteins necessary to maintain cell survival and integrity. The intrinsic pathway occurs when various apoptotic stimuli trigger the release of cytochrome c from the mitochondria (independently of caspase-8 activation). Cytochrome c interacts with Apaf-1 and caspase-9 to promote the activation of caspase-3. Recent studies point to the ER as a third subcellular compartment implicated in apoptotic execution. Alterations in Ca2+ homeostasis and accumulation of misfolded proteins in the ER cause ER stress. Prolonged ER stress can result in the activation of BAD and/or caspase-12, and execute apoptosis. More... |
Gene mapped BioCarta pathways | ||||
ID | Name | Brief Description | Full Description | |
---|---|---|---|---|
IL1R_PATHWAY | il1r pathway | Signal transduction through IL1R | Interleukin-1 (IL-1) is a pro-inflammatory cytokine that sig...... Interleukin-1 (IL-1) is a pro-inflammatory cytokine that signals primarily through the type 1 IL-1 receptor (IL-1R1). The activities of IL-1 include induction of fever, expression of vascular adhesion molecules, and roles in arthritis and septic shock. The inflammatory activities of IL-1 are partially derived by transcriptionally inducing expression of cytokines such as TNF-alpha and interferons, as well as inducing the expression of other inflammation-related genes. There are two forms of IL-1 encoded by distinct genes, IL-1 alpha and IL-1 beta. IL-1 beta is produced as a 269 amino acid precursor that is cleaved by IL-1beta converting enzyme (ICE) to the active IL-1 beta form that is secreted. IL-1 signaling is opposed by the naturally occurring peptide IL-1 receptor antagonist which is a therapeutic agent for the treatment of arthritis. The type 1 IL-1 receptor protein binds IL-1 beta but requires the IL-1 receptor accessory protein (IL-1RAcP) to transduce a signal. IL-1 binding causes activation of two kinases, IRAK-1 and IRAK-2, associated with the IL-1 receptor complex. IRAK-1 (IL-1 Receptor Associated Kinase) activates and recruits TRAF6 to the IL-1 receptor complex. TRAF6 activates two pathways, one leading to NF-kB activation and another leading to c-jun activation. The TRAF associated protein ECSIT leads to c-Jun activation through the Map kinase/JNK signaling system. TRAF6 also signals through the TAB1/TAK1 kinases to trigger the degradation of I-kB, and activation of NF-kB. The IL-1 signaling cascade represents a highly conserved response to pathogens through evolution, with homologs in insects and even in plants. The signal transduction cascade utilized by IL-1 receptor is similar to that of TNF, resulting in NF-kB activation, and is most similar to that of the Toll-like receptors that also participate in inflammatory signaling responses to pathogen components like endotoxin. More... |

Gene | Interactor | Interactor in MK4MDD? | Experiment Type | PMID | |
---|---|---|---|---|---|
IRAK2 | IRAK1 | No | in vivo | 10383454 | |
IRAK2 | IRAK3 | No | in vivo | 10383454 | |
IRAK2 | PELI3 | No | in vitro | 17675297 | |
IRAK2 | TIRAP | No | in vivo | 11544529 | |
IRAK2 | PELI1 | No | in vitro | 17675297 | |
IRAK2 | SMAD2 | No | in vivo | 15761153 | |
IRAK2 | IL1R1 | No | in vitro;in vivo | 9374458 , 12659850 | |
IRAK2 | IRAK2 | Yes | in vivo | 10383454 | |
IRAK2 | TRAF6 | No | in vivo | 9374458 | |
IRAK2 | HRAS | No | in vivo | 11744690 | |
IRAK2 | MYD88 | No | in vitro;in vivo | 9374458 , 12659850 | |
IRAK2 | SMURF1 | No | in vivo | 15761153 | |
IRAK2 | TICAM2 | No | in vitro;in vivo | 12721283 | |
IRAK2 | TLR4 | No | in vivo | 9625770 | |
IRAK2 | PELI2 | No | in vitro | 17675297 |