MK4MDD

Pathway Report

Basic Information
Name Graft-versus-host disease
KEGG Link ID: hsa05332
Name: graft versus_host_disease
Brief Description: Graft-versus-host disease
Full Description: Graft-versus-host disease (GVHD) pathophysiology can be summerized in a three-step process. During step 1, the conditioning regimen (irradiation and/or chemotherapy) leads to damage, activation of host tissues and induction of inflammatory cytokines secretion. Increased expression of major histocompatibility complex (MHC) antigens and adhesion molecules leads to enhancement of the recognition of host MHC and/or minor histocompatibility antigens by mature donor T cells. Donor T-cell activation in step II is characterized by the predominance of Th1 cells and the secretion of IL-2 and IFN-gamma. These cytokines induce further T-cell expansion, induce cytotoxic T lymphocytes (CTL) and natural killer (NK) cells responses and prime additional mononuclear phagocytes to produce TNF-alpha and IL-1. Also, nitric oxide (NO) is produced by activated macrophages, and it may contribute to the tissue damage seen during step 3. Lipopolysaccharide (LPS), which leaks through the intestinal mucosa that was damaged during step 1, together with IFN-gamma, from step 2, further stimulate macrophages to secrete cytokines and NO. During step 3, the effector phase, activated CTL and NK cells mediate cytotoxicity against target host cells through Fas-Fas ligand interactions and perforin-granzyme B.
No. of Studies (Positive/Negative) 1 (1/0) Help

Positive relationship between Graft-versus-host disease and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
Graft-versus-host disease Kao CF, 2012 patients and normal controls We found 17 significantly enriched pathways for depression We found 17 significantly enriched pathways for depression

Positive relationships between Graft-versus-host disease and other components at different levels (count: 0) Help
Positive relationship network of Graft-versus-host disease in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Graft-versus-host disease and MDD (count: 0)
Negative relationships between Graft-versus-host disease and other components at different levels (count: 0) Help
Pathway Graft-versus-host disease related genes in MK4MDD (count: 9)