MK4MDD

Pathway Report

Basic Information
Name GnRH signaling pathway
GO Link ID: GO:0004968
Name: gonadotropin-releasing hormone receptor activity
Type: molecular function
Description Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.
No. of Studies (Positive/Negative) 1 (1/0) Help

Positive relationship between GnRH signaling pathway and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
GnRH signaling pathway Network and C, 2015 patients only FDR q-value=0.0793576 The degree of rank correlation between pathways across pairs...... The degree of rank correlation between pathways across pairs of disorders was significant (Supplementary Tables 4 and 6), with 49 pathways with combined q-value <0.1 spanning the three adult disorders (Table 2, Supplementary Table 7). Of these, 16 are significant at q < 0.05, with the top pathway (GO:51568: histone H3-K4 methylation) having a q = 0.0003 (Table 2). These results are more significant than those observed in any of the disorders analyzed alone. We then use multidimensional scaling (MDS) to cluster these sets in terms of shared genes. More...

Positive relationships between GnRH signaling pathway and other components at different levels (count: 0) Help
Positive relationship network of GnRH signaling pathway in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between GnRH signaling pathway and MDD (count: 0)
Negative relationships between GnRH signaling pathway and other components at different levels (count: 0) Help
Pathway GnRH signaling pathway related genes in MK4MDD (count: 0)